Endometritis

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Endometritis

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Anatomy of the pelvic girdle
Anatomy of the pelvic cavity
Anatomy of the male reproductive organs of the pelvis
Anatomy of the perineum
Anatomy clinical correlates: Male pelvis and perineum
Anatomy of the female urogenital triangle
Anatomy clinical correlates: Female pelvis and perineum
Development of the reproductive system
Prostate gland histology
Testis, ductus deferens, and seminal vesicle histology
Penis histology
Anatomy and physiology of the male reproductive system
Testosterone
Hypospadias and epispadias
Priapism
Prostatitis
Penile cancer
Cryptorchidism
Varicocele
Orchitis
Testicular cancer
Epididymitis
Testicular torsion
Hernias: Clinical
Vaginal and vulvar disorders: Pathology review
Cervical cancer: Pathology review
Cervical cancer
Menstrual cycle
Anatomy and physiology of the female reproductive system
Prostate cancer
Benign prostatic hyperplasia
Inguinal hernia
Ovarian cyst
Premature ovarian failure
Polycystic ovary syndrome
Ovarian torsion
Ovarian sex-cord stromal tumors
Ovarian germ cell tumors
Ovarian surface epithelial tumors
Endometritis
Endometrial cancer
Endometriosis
Endometrial hyperplasia
Choriocarcinoma
Uterine fibroid
Testicular tumors: Pathology review
Uterine disorders: Pathology review
Ovarian cysts and tumors: Pathology review
Amenorrhea
Amenorrhea: Clinical
Amenorrhea: Pathology review
Ectopic pregnancy
Virilization: Clinical
Abnormal uterine bleeding: Clinical
Haemophilus ducreyi (Chancroid)
Treponema pallidum (Syphilis)
Herpes simplex virus
Chlamydia trachomatis
Gardnerella vaginalis (Bacterial vaginosis)
Neisseria gonorrhoeae
Candida
Trichomonas vaginalis
Arteries and veins of the pelvis
Nerves and lymphatics of the pelvis
Anatomy of the inguinal region
Anatomy of the male urogenital triangle
Anatomy of the breast
Anatomy clinical correlates: Breast
Mammary gland histology
Ovary histology
Fallopian tube and uterus histology
Cervix and vagina histology
Puberty and Tanner staging
Estrogen and progesterone
Menopause
Pregnancy
Oxytocin and prolactin
Stages of labor
Breastfeeding
Erectile dysfunction
Male hypoactive sexual desire disorder
Female sexual interest and arousal disorder
Pelvic inflammatory disease
Urethritis
Androgens and antiandrogens
Adrenergic antagonists: Alpha blockers
PDE5 inhibitors
Estrogens and antiestrogens
Progestins and antiprogestins
Aromatase inhibitors
Sexually transmitted infections: Clinical
Human development days 1-4
Human development days 4-7
Human development week 2
Human development week 3
Infertility: Clinical
Placenta previa
Development of the placenta
Turner syndrome
Klinefelter syndrome
Fragile X syndrome
Ovarian cysts, cancer, and other adnexal masses: Clinical
Galactosemia
Hyperemesis gravidarum
Complications during pregnancy: Pathology review
Vulvovaginitis: Clinical
Endometrial hyperplasia and cancer: Clinical
Cervical cancer: Clinical
Vaginal cancer: Clinical
Vulvar cancer: Clinical
Fetal circulation
Preeclampsia & eclampsia
Hypertensive disorders of pregnancy: Clinical
Uterine stimulants and relaxants
cGMP mediated smooth muscle vasodilators
Postpartum hemorrhage: Clinical
Placenta accreta
Placental abruption
Antepartum hemorrhage: Clinical
Abnormal labor: Clinical
Gestational trophoblastic disease: Clinical
Krukenberg tumor
Breast cancer: Pathology review
Benign breast conditions: Pathology review
Breast cancer
Fibrocystic breast changes
Breast cancer: Clinical
Anatomy of the female reproductive organs of the pelvis
Precocious puberty
Delayed puberty
Androgen insensitivity syndrome
5-alpha-reductase deficiency
Kallmann syndrome
Bladder exstrophy
Orgasmic dysfunction
Genito-pelvic pain and penetration disorder
Mastitis
Intraductal papilloma
Phyllodes tumor
Paget disease of the breast
Gestational hypertension
Gestational diabetes
Cervical incompetence
Oligohydramnios
Polyhydramnios
Potter sequence
Intrauterine growth restriction
Preterm labor
Postpartum hemorrhage
Chorioamnionitis
Congenital toxoplasmosis
Congenital cytomegalovirus (NORD)
Congenital syphilis
Neonatal conjunctivitis
Neonatal herpes simplex
Congenital rubella syndrome
Neonatal sepsis
Neonatal meningitis
Miscarriage
Gestational trophoblastic disease
Fetal hydantoin syndrome
Fetal alcohol syndrome
Disorders of sex chromosomes: Pathology review
Prostate disorders and cancer: Pathology review
Congenital TORCH infections: Pathology review
Disorders of sexual development and sex hormones: Pathology review
Testicular and scrotal conditions: Pathology review

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Endometritis is an inflammation of the endometrium, which is the inner lining of the uterus.

It is usually caused by an infection of the endometrium from bacteria that normally live in the female lower genital tract, but it could also be caused by bacteria from outside the body.

The female reproductive system is divided into upper and lower genital tracts.

The upper genital tract consists of the uterus, ovaries, and fallopian tubes.

The lower genital tract in turn consists of the cervix, vagina and the external genitals, which includes the labia and the clitoris.

Now, The uterus consists of 3 layers, an outer thin layer called the perimetrium or the serosa, a middle smooth muscle layer called the myometrium, and the innermost layer, the endometrium.

The endometrium has two layers, an inner functional layer made up mainly of glands and supporting connective tissue, called stroma, and an outer thin basal layer which regenerates the overlying functional layer after each menstrual cycle.

Alright, normally, there are many species of bacteria living in the female’s lower genital tract, and this is called the normal flora.

These include Ureaplasma urealyticum, Peptostreptococcus and group B Streptococcus.

Under normal conditions, these bacteria live there happily without causing any harm, however, if they reach the upper genital tract, they can cause an infection like endometritis if they make it to the uterus.

Endometritis is a common problem during pregnancy because bacteria can easily reach the uterus during childbirth.

Okay, so normally the fetus is surrounded by membranes and amniotic fluid, and the uterus’s opening is sealed by a mucous plug.

This mucus plug has antimicrobial properties, preventing bacteria from reaching the uterus. Typically, during vaginal delivery, the mucus plug is shed, the cervix widens, and the membranes around the fetus rupture, so the baby can be delivered.

However, bacteria in the lower genital tract can take advantage of this, and sneak through the opening up to the uterus, causing endometritis.

To make matters worse, under certain conditions, bacteria can have even more time to reach the endometrium.

This can occur when there’s prolonged labor, and premature rupture of membranes, where the membranes around the fetus have ruptured before the onset of labor.

In addition, if the amniotic fluid or the membranes around the fetus become infected, a condition known as chorioamnionitis, the infection can spread to the nearby endometrium causing it to be infected as well.

In addition, people who give birth by cesarean section are even more likely to have endometritis after childbirth.

This is because cesarean section makes it easier for the bacteria in the lower genital tract to reach the endometrium, and even bacteria from outside the body can make their way in.

Endometritis can also occur when placental or fetal tissues are not completely removed from the uterus after delivery or abortion.

These tissues provide a good environment for bacteria to grow and cause an infection in the uterus.

Now, apart from childbirth, there are other factors that makes it easier for bacteria from the lower genital tract to reach the endometrium, even in non-pregnant females.

This can occur during hysteroscopy, where the inside of the uterus is viewed using a camera inserted through the vagina, and when there’s an intrauterine contraceptive device, which has a thread that reaches down to the cervix or the vagina.

When these devices are inserted into the uterus, they might introduce forign bacteria accidentally.

Finally, endometritis can be caused by outside bacteria such as Chlamydia trachomatis or Neisseria gonorrhoeae, which are sexually transmitted infections.

Also, some cases of endometritis can occur in a female with tuberculosis, in which Mycobacterium tuberculosis spreads from the lungs into the blood and travels to other organs such as the uterus.

Alright, endometritis can be acute or chronic. People with acute endometritis, can present with fever, abnormal uterine bleeding, lower abdominal pain, dysuria, which is painful urination, or dyspareunia, which means pain during sexual intercourse.

When endometritis occurs after childbirth, the lochia, which is the normal vaginal discharge after giving birth, can become purulent, meaning yellowish, and foul smelling.

Key Takeaways

Endometritis refers to inflammation of the endometrium, the inner lining of the uterus. It is usually caused by normal flora of the genital tract if the endometrium is breached, but can also be caused by sexually transmitted infections, such as Chlamydia trachomatis and Neisseria gonorrhoeae infections.

Common symptoms are fever, pain in the pelvis or lower abdomen, abnormal vaginal discharge, and painful sexual intercourse. Procedures which can lacerate the endometrium such as childbirth, abortion, surgery on the uterus or other pelvic organs, and insertion of an intrauterine contraceptive device (IUD), all increase a chance of having endometritis.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
  5. "An in vitro study of antibacterial properties of the cervical mucus plug in pregnancy" American Journal of Obstetrics and Gynecology (2001)
  6. "The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology" American Journal of Obstetrics and Gynecology (2018)