Trauma- and stress-related disorders: Pathology review

Last updated: September 12, 2024

Trauma- and stress-related disorders: Pathology review

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Anatomical terminology
Joints of the ankle and foot
Anatomy of the tibiofibular joints
DNA structure
DNA replication
Hair, skin and nails
Wound healing
Estrogens and antiestrogens
Skin cancer
Chronic granulomatous disease
Plasmodium species (Malaria)
VDJ rearrangement
Bile secretion and enterohepatic circulation
Normal heart sounds
Ascending and descending spinal tracts
Somatosensory pathways
Anatomy of the diencephalon
Independent assortment of genes and linkage
Anatomy of the cerebral cortex
Anatomy of the ventricular system
Basal ganglia: Direct and indirect pathway of movement
Anatomy of the basal ganglia
Anatomy of the descending spinal cord pathways
Anatomy of the ascending spinal cord pathways
Movement disorders: Pathology review
Eye conditions: Refractive errors, lens disorders and glaucoma: Pathology review
Anatomy of the eye
Anatomy of the oculomotor (CN III), trochlear (CN IV) and abducens (CN VI) nerves
Anatomy and physiology of the ear
Auditory transduction and pathways
Anatomy of the inner ear
Ischemic stroke
Stroke: Clinical
Anatomy of the brainstem
Anatomy of the limbic system
Pediatric ophthalmological conditions: Clinical
Anatomy of the nose and paranasal sinuses
Schizophrenia spectrum disorders: Clinical
Spinocerebellar ataxia (NORD)
Anatomy clinical correlates: Cerebellum and brainstem
Anatomy of the pharynx and esophagus
Somatic symptom disorders: Clinical
Malingering, factitious disorders and somatoform disorders: Pathology review
Factitious disorder
Major depressive disorder
Suicide
Major depressive disorder with seasonal pattern
Insomnia
Developmental and learning disorders: Pathology review
Childhood and early-onset psychological disorders: Pathology review
Disorders of consciousness: Clinical
Brain herniation
Epidural hematoma
Subdural hematoma
Subarachnoid hemorrhage
Hernias: Clinical
Hypothyroidism
ADHD: Information for patients and families (The Primary School)
Attention deficit hyperactivity disorder
Neurodevelopmental disorders: Clinical
Autism spectrum disorder
Bipolar and related disorders
Mood disorders: Clinical
Pediatric upper airway conditions: Clinical
Upper respiratory tract infection
Superficial structures of the neck: Anterior triangle
Superficial structures of the neck: Posterior triangle
Anxiety disorders: Clinical
Anxiety disorders, phobias and stress-related disorders: Pathology Review
Generalized anxiety disorder
Anatomy of the facial nerve (CN VII)
Bell palsy
Cranial nerves rap
Anatomy of the infratemporal fossa
Anatomy of the trigeminal nerve (CN V)
Temporomandibular joint dysfunction
Anatomy of the temporomandibular joint and muscles of mastication
Allergic rhinitis
Nasal polyps
Sinusitis
Rhinovirus
Nasal, oral and pharyngeal diseases: Pathology review
Pancoast tumor
Laryngitis
Laryngomalacia
Trauma- and stress-related disorders: Pathology review
Trauma- and stressor-related disorders: Clinical
Traumatic brain injury: Clinical
Dementia: Pathology review
Meningitis
Meningitis, encephalitis and brain abscesses: Clinical
Abscesses
Seizures: Pathology review
Seizures: Clinical
Febrile seizure
Sleep disorders: Clinical
Narcolepsy (NORD)
Sleep apnea
Syncope: Clinical
Anatomy clinical correlates: Oculomotor (CN III), trochlear (CN IV) and abducens (CN VI) nerves
Kidney histology
Hypertension
Movement of water between body compartments
Body fluid compartments
Glucocorticoids
Mineralocorticoids and mineralocorticoid antagonists
Adrenocorticotropic hormone
Regulation of renal blood flow
Hydration
Synthesis of adrenocortical hormones
Cortisol
Vitamin D
Renal system anatomy and physiology
Renal clearance
Complement system
Hyponatremia
Hyponatremia: Clinical
Hypernatremia
Hypernatremia: Clinical
Electrolyte disturbances: Pathology review
Hypokalemia
Hypokalemia: Clinical
Hyperkalemia
Hyperkalemia: Clinical
Action potentials in myocytes
Cardiac conduction system
Hyperparathyroidism
ECG cardiac infarction and ischemia
Myocardial infarction
Pericarditis and pericardial effusion
Pleural effusion
Long QT syndrome and Torsade de pointes
Cardiovascular: Pulse (for nursing assistant training)
Atherosclerosis and arteriosclerosis: Pathology review
Arterial disease
Aneurysms
Ischemia
Deep vein thrombosis
Familial hypercholesterolemia
Hypercholesterolemia: Clinical
Dyslipidemias: Pathology review
Kidney countercurrent multiplication
Insulins
Diabetes mellitus
Diabetes mellitus: Pathology review
Pulmonary embolism
Deep vein thrombosis and pulmonary embolism: Pathology review
Wolff-Parkinson-White syndrome
Thyroid and parathyroid gland histology
Thyroid hormones
Hypothyroidism: Pathology review
Hyperthyroidism: Pathology review
Hyperthyroidism: Clinical
Toxic multinodular goiter
Thyroid nodules and thyroid cancer: Clinical
Coagulation (secondary hemostasis)
Platelet plug formation (primary hemostasis)
Helping a patient with a rare disease
Diabetes mellitus: Clinical
Pancreas histology
Pancreatic secretion
Endocrine system anatomy and physiology
Miscellaneous hypoglycemics
Hypopituitarism
Hypopituitarism: Pathology review
Hypopituitarism: Clinical
Pituitary adenoma
Acromegaly
Gigantism
Diabetes insipidus and SIADH: Pathology review
Hypoglycemics: Insulin secretagogues
Liver histology
Liver anatomy and physiology
Cirrhosis
Cirrhosis: Pathology review
Cirrhosis: Clinical
Alcohol-associated liver disease
Primary biliary cholangitis
Parathyroid disorders and calcium imbalance: Pathology review
Phosphate, calcium and magnesium homeostasis
Parathyroid conditions and calcium imbalance: Clinical
Parathyroid hormone
Hypocalcemia
Hypercalcemia
Jaundice
Jaundice: Pathology review
Jaundice: Clinical
Hepatitis A and Hepatitis E virus
Hepatitis B and Hepatitis D virus
Hepatitis C virus
Adrenal gland histology
Primary adrenal insufficiency
Adrenal insufficiency: Pathology review
Adrenal insufficiency: Clinical
Cushing syndrome and Cushing disease: Pathology review
Cushing syndrome
Pheochromocytoma
Hyperaldosteronism
Gallstone ileus
Gallstones
Gallbladder disorders: Pathology review
Biliary colic
Ascending cholangitis
Gastrointestinal system anatomy and physiology
Clinical Skills: Abdominal Assessment
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Peptic ulcers and stomach cancer: Clinical
Gastric cancer
Gastrointestinal bleeding: Pathology review
Gastrointestinal bleeding: Clinical
Hashimoto thyroiditis
Chronic pancreatitis
Pancreatitis: Pathology review
Pancreatitis: Clinical
Acute pancreatitis
Pancreatic cancer
Malabsorption syndromes: Pathology review
Malabsorption: Clinical
Celiac disease
Short bowel syndrome (NORD)
Esophageal disorders: Clinical
Esophageal disorders: Pathology review
Gastroesophageal reflux disease (GERD)
Gastroesophageal reflux disease (GERD): Clinical
Eosinophilic esophagitis (NORD)
Diverticular disease: Pathology review
Anatomy of the gastrointestinal organs of the pelvis and perineum
Lesch-Nyhan syndrome
Sjogren syndrome
Non-steroidal anti-inflammatory drugs
Antihistamines for allergies
Eczematous rashes: Clinical
Atopic dermatitis
Urinary tract infections: Pathology review
Urinary tract infections: Clinical
Lower urinary tract infection
Papulosquamous and inflammatory skin disorders: Pathology review
Mechanisms of antibiotic resistance
Erythema multiforme
Congenital TORCH infections: Pathology review
Severe chronic neutropenia (NORD)
Lung cancer
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Clinical
Anaphylaxis
Epigenetics
Cell signaling pathways
Cell cycle
Necrosis and apoptosis
Human papillomavirus
Atrophy, aplasia, and hypoplasia
Estrogen and progesterone
Testosterone
Androgens and antiandrogens
Anatomy of the female urogenital triangle
Anatomy of the female reproductive organs of the pelvis
Anatomy and physiology of the female reproductive system
Cellulitis and erysipelas: Clinical sciences
Mesoderm
Development of the axial skeleton
Spinal cord disorders: Pathology review
Chest trauma: Clinical
Shock: Pathology review
Shock
Hypovolemic shock: Clinical sciences
Portal hypertension
Metabolic acidosis
Pulmonary embolism: Clinical sciences
Marfan syndrome
Anticoagulants: Heparin
Anticoagulants: Warfarin
Abdominal aortic aneurysm: Clinical sciences
Reading a chest X-ray
Chest X-ray interpretation: Clinical sciences
Approach to dyspnea: Clinical sciences
Bulimia nervosa
Anorexia nervosa
Lung volumes and capacities
Deep vein thrombosis: Clinical sciences
ECG basics
Multiple organ dysfunction syndrome (MODS): Clinical sciences
Sepsis: Clinical sciences
Stomach histology
Approach to non-healing wounds: Clinical sciences
Assessment of Thorax and Lungs
Bacterial and viral skin infections: Pathology review
Cellulitis
Necrotizing soft tissue infections: Clinical sciences
Necrotizing fasciitis
Clostridium perfringens
General anesthetics
Local anesthetics
Nitrogen and urea cycle
Surgical site infection: Clinical sciences
Disseminated intravascular coagulation
Congenital neurological disorders: Pathology review
Puberty and Tanner staging
Precocious puberty
Turner syndrome
Turner syndrome: Year of the Zebra
Disorders of sexual development and sex hormones: Pathology review
Congenital adrenal hyperplasia
5-alpha-reductase deficiency
Klinefelter syndrome
Disorders of sex chromosomes: Pathology review
Brachial plexus
Neonatal meningitis
Development of the fetal membranes
cGMP mediated smooth muscle vasodilators
Down syndrome (Trisomy 21)
Autosomal trisomies: Pathology review
Taking a good patient history
Chlamydia trachomatis infection: Clinical sciences
Sexually transmitted infections: Vaginitis and cervicitis: Pathology review
Neisseria gonorrhoeae infection: Clinical sciences
Testis, ductus deferens, and seminal vesicle histology
Anatomy and physiology of the male reproductive system
Hypoparathyroidism
Protein-calorie malnutrition: Clinical sciences
Zinc deficiency and protein-energy malnutrition: Pathology review
Water-soluble vitamin deficiency and toxicity: B1-B7: Pathology review
Water-soluble vitamin deficiency and toxicity: B9, B12 and vitamin C: Pathology review
Fat-soluble vitamin deficiency and toxicity: Pathology review
Disorders of carbohydrate metabolism: Pathology review
Galactosemia
Cholestatic liver disease
Infectious gastroenteritis: Clinical sciences
Cyclic vomiting syndrome (NORD)
Viral hepatitis
Hepatitis medications
Hepatitis C: Clinical sciences
Uremic encephalopathy: Clinical sciences
Alagille syndrome (NORD)
Alagille syndrome (NORD): Year of the Zebra
Adrenal insufficiency: Clinical sciences
Achondroplasia
Anatomy of the lymphatics of the neck
Anatomy of the inguinal region
Lymphatic system anatomy and physiology
Introduction to the lymphatic system
Kawasaki disease
Bordetella pertussis (Whooping cough)
Cystic fibrosis: Pathology review
Miscellaneous genetic disorders: Pathology review
Fragile X syndrome
Measles virus
Epstein-Barr virus (Infectious mononucleosis)
Disruptive, impulse control, and conduct disorders
Approach to syncope: Clinical sciences
Glycogen storage disease type I
Glycogen storage disease type II (NORD)
Disorders of fatty acid metabolism: Pathology review
Spinal muscular atrophy
Approach to urinary incontinence (GYN): Clinical sciences
Approach to hypothyroidism: Clinical sciences
Hypothyroidism medications
Approach to hyperthyroidism and thyrotoxicosis: Clinical sciences
Thyroid carcinoma: Clinical sciences
Anatomy clinical correlates: Anterior and posterior abdominal wall
Approach to abdominal wall and groin masses: Clinical sciences
Inguinal hernias: Clinical sciences
Approach to a postoperative fever: Clinical sciences
Chronic venous insufficiency
Venous insufficiency and ulcers: Clinical sciences

Transcript

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A 31 year old female named Amelia comes to the mental health clinic complaining of trouble sleeping due to vivid nightmares recounting an armed bank robbery she witnessed 4 months ago.

Ever since that event, she has avoided going to crowded places that remind her of the bank, to the point where she had to give up her job at the mall.

Suddenly, your phone starts ringing and Amelia jumps from her seat. You apologize, and she then mentions that this happens whenever she hears sudden or loud noises.

Okay, based on the initial presentation, Amelia seems to have some form of trauma or stress-related disorder.

Many individuals at some point in their lives experience trauma, which can be thought of as a distressing event that causes an overwhelming amount of stress, exceeding one’s ability to cope or process the emotions caused by that experience.

Trauma can be caused by one single event, such as a serious car crash or sexual assault or abuse; or can last for a more prolonged period of time, such as experiencing poverty, neglect during early childhood, or military combat.

Most of the time, with support from loved ones, individuals are able to recover from a traumatic experience.

Unfortunately, some individuals may develop trauma and stress-related disorders, where traumatic experiences lead to symptoms like flashbacks, nightmares, and anxiety, all of which can interfere with day-to-day activities like working, studying, eating, and sleeping.

Now, the underlying cause of trauma and stress-related disorders is poorly understood; but what you need to remember is that individuals affected usually have altered levels and response to stress hormones like adrenaline and cortisol.

For your exams, the most high-yield trauma and stress-related disorders are post-traumatic stress disorder, acute stress disorder, and adjustment disorder. Okay, let’s start with post-traumatic stress disorder, or PTSD for short.

This usually occurs in individuals who have either directly experienced a traumatic event or witnessed as it happened to others, but it can also affect someone who just heard that a close family member or friend was involved.

In a test question, make sure to also keep an eye out for someone with prolonged or extreme exposure to graphic details of traumatic events, such as a police officer or paramedic, as well as a military veteran.

Now, symptoms of PTSD must last for at least one month and they mainly include recurrent, involuntary, and intrusive memories of the traumatic experience through nightmares or flashbacks.

When exposed to physical or mental reminders of their trauma, these individuals typically experience intense psychological distress or physical reactions, such as sweating and heart palpitations.

For your exams, what’s important to remember is that this may cause them to feel a sense of hypervigilance, meaning that they are constantly on guard, as well as hyperarousal, where they have this exaggerated startle response to the smallest of triggers, such as sudden or loud noises.

Another high yield fact is that individuals with PTSD may start avoiding environments and situations that remind them of their trauma, such as certain places, activities, or even other people.

Finally, thinking and mood might be negatively affected, so individuals may have exaggerated negative beliefs about oneself, others, or the world, like thinking the world is completely dangerous and no one can be trusted; or persistent negative emotions such as fear, distress, or shame.

Moving on to acute stress disorder, this also occurs in individuals who have either directly experienced or witnessed one or repeated traumatic events, or heard about it through a close family member or friend.

Acute stress disorder causes many of the same trauma-related symptoms as PTSD, but a key difference you need to remember for your exams is that the symptoms only last between 3 days and up to 1 month following the traumatic event.

Last but not least, there’s adjustment disorders, which are a group of disorders that occur after an individual goes through a stressful or life-changing event, to which they have a hard time adjusting or coping.

Now, events can range from a divorce or losing a job to being diagnosed with an illness.

Key Takeaways

Trauma- and stress-related disorders are a group of mental health conditions that can occur as a result of exposure to traumatic or stressful events. This group of disorders includes post-traumatic stress disorder (PTSD), acute stress disorder, adjustment disorders, and reactive attachment disorder.

Both PTSD and acute stress disorder can affect individuals who have experienced prolonged traumatic events, especially involving a close family member or friend. Symptoms include recurrent, involuntary, and intrusive memories associated with nightmares or flashbacks; as well as intense psychological distress or physical reactions. People with these two disorders can also present with hypervigilance or hyperarousal; avoidance behavior; and negative alterations in thinking or mood. What differentiates PTSD from acute stress disorder is that in PTSD, the symptoms must last for more than one month, while in acute stress disorder, they should last at least three days but less than one month following the traumatic event.

Next, we have adjustment disorder, which is characterized by emotional or behavioral symptoms in response to a stressor or life change. Symptoms typically develop within three months of a stressful or life-changing event and resolve within six months. There is also reactive attachment disorder, which typically affects infants or young children who don't get attached to their caregivers. The symptoms appear following the lack of adequate care or neglect and are often evident in young children between the age of nine months and five years. Treatment of trauma and stress-related disorders typically includes cognitive behavioral therapy and lifestyle changes. It can also involve medications like selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs).

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Diagnostic and Statistical Manual of Mental Disorders" NA (1980)
  4. "Post-traumatic stress disorder" BMJ (2015)
  5. "Suicidality and posttraumatic stress disorder (PTSD) in adolescents: a systematic review and meta-analysis" Social Psychiatry and Psychiatric Epidemiology (2014)
  6. "Current status on behavioral and biological markers of PTSD: A search for clarity in a conflicting literature" Neuroscience & Biobehavioral Reviews (2013)
  7. "Wilderness and Rescue Medicine" Jones & Bartlett Publishers (2012)
  8. "Adjustment disorder as proposed for ICD-11: Dimensionality and symptom differentiation" Psychiatry Research (2015)
  9. "Adjustment Disorder: Current Developments and Future Directions" International Journal of Environmental Research and Public Health (2019)