Trauma- and stress-related disorders: Pathology review

Last updated: September 12, 2024

Trauma- and stress-related disorders: Pathology review

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Glycolysis
Citric acid cycle
Electron transport chain and oxidative phosphorylation
Nitrogen and urea cycle
Respiratory alkalosis
Respiratory acidosis
Respiratory system anatomy and physiology
Lung volumes and capacities
Compliance of lungs and chest wall
Restrictive lung diseases
Regulation of pulmonary blood flow
The role of the kidney in acid-base balance
Renal system anatomy and physiology
Sodium homeostasis
Cardiovascular system anatomy and physiology
Blood pressure, blood flow, and resistance
Resistance to blood flow
Microcirculation and Starling forces
Cardiac afterload
Frank-Starling relationship
Stroke volume, ejection fraction, and cardiac output
Measuring cardiac output (Fick principle)
Cardiac conduction system
ECG intervals
Muscle contraction
Slow twitch and fast twitch muscle fibers
Neuron action potential
Renal clearance
Glomerular filtration
Measuring renal plasma flow and renal blood flow
Regulation of renal blood flow
Loop of Henle
Proximal convoluted tubule
Distal convoluted tubule
Potassium homeostasis
Phosphate, calcium and magnesium homeostasis
Renin-angiotensin-aldosterone system
Antidiuretic hormone
Buffering and Henderson-Hasselbalch equation
Physiologic pH and buffers
Acid-base map and compensatory mechanisms
Alveolar surface tension and surfactant
Combined pressure-volume curves for the lung and chest wall
Pulmonary changes during exercise
Pulmonary changes at high altitude and altitude sickness
Mitosis and meiosis
Inheritance patterns
Cystic fibrosis
Action potentials in pacemaker cells
Cardiac cycle
Action potentials in myocytes
Cardiac excitation-contraction coupling
Changes in pressure-volume loops
Arteriole, venule and capillary histology
Baroreceptors
Chemoreceptors
Pressures in the cardiovascular system
Excitability and refractory periods
Normal heart sounds
Abnormal heart sounds
Cholinergic receptors
Parasympathetic nervous system
Antimalarials
Antimetabolites for cancer treatment
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Antimetabolites: Sulfonamides and trimethoprim
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Extrinsic hemolytic normocytic anemia: Pathology review
Anti-mite and louse medications
Amnesia, dissociative disorders and delirium: Pathology review
Childhood and early-onset psychological disorders: Pathology review
Developmental and learning disorders: Pathology review
Drug misuse, intoxication and withdrawal: Alcohol: Pathology review
Drug misuse, intoxication and withdrawal: Hallucinogens: Pathology review
Drug misuse, intoxication and withdrawal: Other depressants: Pathology review
Drug misuse, intoxication and withdrawal: Stimulants: Pathology review
Eating disorders: Pathology review
Malingering, factitious disorders and somatoform disorders: Pathology review
Mood disorders: Pathology review
Personality disorders: Pathology review
Psychiatric emergencies: Pathology review
Psychological sleep disorders: Pathology review
Schizophrenia spectrum disorders: Pathology review
Trauma- and stress-related disorders: Pathology review
Environmental and chemical toxicities: Pathology review
Medication overdoses and toxicities: Pathology review

Questions

USMLE® Step 1 style questions USMLE

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A 23-year-old woman comes to her primary care physician to evaluate recurrent nightmares. The patient was sexually assaulted two weeks ago, and since that time, reports recurrent nightmares surrounding the event. She states, “Ever since the incident, I can’t return to campus. The thought of being back at school after what happened is unbearable.” The patient avoids thinking about the incident and feels depressed, irritable, and distracted throughout the day. The patient has not had any suicidal ideation or thoughts. The patient has no past medical history. Which of the following is the most likely diagnosis?  

Transcript

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A 31 year old female named Amelia comes to the mental health clinic complaining of trouble sleeping due to vivid nightmares recounting an armed bank robbery she witnessed 4 months ago.

Ever since that event, she has avoided going to crowded places that remind her of the bank, to the point where she had to give up her job at the mall.

Suddenly, your phone starts ringing and Amelia jumps from her seat. You apologize, and she then mentions that this happens whenever she hears sudden or loud noises.

Okay, based on the initial presentation, Amelia seems to have some form of trauma or stress-related disorder.

Many individuals at some point in their lives experience trauma, which can be thought of as a distressing event that causes an overwhelming amount of stress, exceeding one’s ability to cope or process the emotions caused by that experience.

Trauma can be caused by one single event, such as a serious car crash or sexual assault or abuse; or can last for a more prolonged period of time, such as experiencing poverty, neglect during early childhood, or military combat.

Most of the time, with support from loved ones, individuals are able to recover from a traumatic experience.

Unfortunately, some individuals may develop trauma and stress-related disorders, where traumatic experiences lead to symptoms like flashbacks, nightmares, and anxiety, all of which can interfere with day-to-day activities like working, studying, eating, and sleeping.

Now, the underlying cause of trauma and stress-related disorders is poorly understood; but what you need to remember is that individuals affected usually have altered levels and response to stress hormones like adrenaline and cortisol.

For your exams, the most high-yield trauma and stress-related disorders are post-traumatic stress disorder, acute stress disorder, and adjustment disorder. Okay, let’s start with post-traumatic stress disorder, or PTSD for short.

This usually occurs in individuals who have either directly experienced a traumatic event or witnessed as it happened to others, but it can also affect someone who just heard that a close family member or friend was involved.

In a test question, make sure to also keep an eye out for someone with prolonged or extreme exposure to graphic details of traumatic events, such as a police officer or paramedic, as well as a military veteran.

Now, symptoms of PTSD must last for at least one month and they mainly include recurrent, involuntary, and intrusive memories of the traumatic experience through nightmares or flashbacks.

When exposed to physical or mental reminders of their trauma, these individuals typically experience intense psychological distress or physical reactions, such as sweating and heart palpitations.

For your exams, what’s important to remember is that this may cause them to feel a sense of hypervigilance, meaning that they are constantly on guard, as well as hyperarousal, where they have this exaggerated startle response to the smallest of triggers, such as sudden or loud noises.

Another high yield fact is that individuals with PTSD may start avoiding environments and situations that remind them of their trauma, such as certain places, activities, or even other people.

Finally, thinking and mood might be negatively affected, so individuals may have exaggerated negative beliefs about oneself, others, or the world, like thinking the world is completely dangerous and no one can be trusted; or persistent negative emotions such as fear, distress, or shame.

Moving on to acute stress disorder, this also occurs in individuals who have either directly experienced or witnessed one or repeated traumatic events, or heard about it through a close family member or friend.

Acute stress disorder causes many of the same trauma-related symptoms as PTSD, but a key difference you need to remember for your exams is that the symptoms only last between 3 days and up to 1 month following the traumatic event.

Last but not least, there’s adjustment disorders, which are a group of disorders that occur after an individual goes through a stressful or life-changing event, to which they have a hard time adjusting or coping.

Now, events can range from a divorce or losing a job to being diagnosed with an illness.

Key Takeaways

Trauma- and stress-related disorders are a group of mental health conditions that can occur as a result of exposure to traumatic or stressful events. This group of disorders includes post-traumatic stress disorder (PTSD), acute stress disorder, adjustment disorders, and reactive attachment disorder.

Both PTSD and acute stress disorder can affect individuals who have experienced prolonged traumatic events, especially involving a close family member or friend. Symptoms include recurrent, involuntary, and intrusive memories associated with nightmares or flashbacks; as well as intense psychological distress or physical reactions. People with these two disorders can also present with hypervigilance or hyperarousal; avoidance behavior; and negative alterations in thinking or mood. What differentiates PTSD from acute stress disorder is that in PTSD, the symptoms must last for more than one month, while in acute stress disorder, they should last at least three days but less than one month following the traumatic event.

Next, we have adjustment disorder, which is characterized by emotional or behavioral symptoms in response to a stressor or life change. Symptoms typically develop within three months of a stressful or life-changing event and resolve within six months. There is also reactive attachment disorder, which typically affects infants or young children who don't get attached to their caregivers. The symptoms appear following the lack of adequate care or neglect and are often evident in young children between the age of nine months and five years. Treatment of trauma and stress-related disorders typically includes cognitive behavioral therapy and lifestyle changes. It can also involve medications like selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs).

Sources

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  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Diagnostic and Statistical Manual of Mental Disorders" NA (1980)
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  6. "Current status on behavioral and biological markers of PTSD: A search for clarity in a conflicting literature" Neuroscience & Biobehavioral Reviews (2013)
  7. "Wilderness and Rescue Medicine" Jones & Bartlett Publishers (2012)
  8. "Adjustment disorder as proposed for ICD-11: Dimensionality and symptom differentiation" Psychiatry Research (2015)
  9. "Adjustment Disorder: Current Developments and Future Directions" International Journal of Environmental Research and Public Health (2019)