Kidney disease refers to kidney damage that decreases its function (e.g., the ability to filter waste, such as urea, ions, and excess water from the blood). Most individuals usually do not present with severe symptoms until their kidney disease has progressed. Common symptoms of late-stage kidney disease include fatigue; trouble concentrating; poor appetite; difficulty sleeping; swollen feet and ankles; puffiness around the eyes; dry, itchy skin; or increased frequency of urination, especially at night. If kidney disease progresses, complications like fluid retention; high blood pressure; fluid accumulation in the lungs (i.e., pulmonary edema); a rise in potassium levels in the blood (i.e., hyperkalemia); or low blood count (i.e., anemia) can occur.
Kidney disease can be classified as either acute or chronic. Acute kidney injury (AKI), also known as acute renal failure (ARF), refers to a sudden and often reversible decrease in kidney function, which involves both injury (i.e., structural damage) and functional impairment. The degree of injury is usually measured by an increased creatinine or decreased urine volume; however, it rarely has a distinct pathophysiology. The pathology can be either identified as pre-renal (e.g., hypovolemia, impaired cardiac function, systemic vasodilation, increased vascular resistance); intrinsic (e.g., renal ischemia, nephrotoxic drugs, infections, vascular diseases); and post-renal (e.g., external and internal obstruction like nephrolithiasis, or prostate hypertrophy). Renal cellular damage may occur if these pre- or post-renal conditions persist, causing intrinsic renal disease.
Chronic kidney disease (CKD), on the other hand, is defined by the persistence of kidney damage or an estimated glomerular filtration rate (i.e., eGFR, which evaluates the kidney’s function by calculating the blood filtered by the glomeruli per minute) < 60 ml/min per 1.73 m2, for at least three months. It is a progressive state of kidney function loss due to chronic or persistent damage from conditions such as diabetes mellitus, high blood pressure, recurrent kidney infections, or polycystic kidney disease, eventually resulting in renal replacement therapy (e.g., dialysis or kidney transplantation).
Treatment of kidney disease depends on each cause and its severity. Individuals may be advised to increase or decrease their intake of water and other fluids; make lifestyle changes to remain as healthy as possible; and adjust their medications according to their needs (e.g., control blood pressure, decrease cholesterol, stop nephrotoxic agents); or treat underlying infections with antibiotics (e.g., ciprofloxacin or co-amoxiclav). In advanced CKD, dialysis or a kidney transplant may be necessary.