00:00 / 00:00
|TRIMETHOPRIM AND SULFONAMIDES|
|DRUG NAME||silver sulfadiazine (Silvadene); sulfadiazine||trimethoprim-sulfamethoxazole (Bactrim)|
*High Risk Medication
(pediatric / geriatric)*
|MECHANISM OF ACTION|
|ROUTE(S) OF ADMINISTRATION|
|CONTRAINDICATIONS AND CAUTIONS|
|NURSING CONSIDERATIONS: TRIMETHOPRIM AND SULFONAMIDES|
|DRUG NAME||trimethoprim-sulfamethoxazole for UTI|
|ASSESSMENT AND MONITORING||Assessment|
TMP-SMX is most commonly used to treat acute and simple urinary tract infections or UTIs, acute otitis media, traveler's diarrhea, and shigellosis. But it’s also effective in treating pneumonia and sinus infections caused by Streptococcus pneumoniae and Haemophilus influenzae.
It’s the first line therapy for the treatment and prevention of Pneumocystis jirovecii infections, which are caused by a yeast-like fungus that can affect immunocompromised people. Finally, it’s effective against Methicillin-Resistant Staphylococcus aureus, or MRSA.
Now, sulfonamides can also be used alone as sulfadiazine orally to treat infection by Toxoplasma gondii, or as silver sulfadiazine, which is administered topically in clients with second and third-degree burns to help prevent and treat wound sepsis.
Now, once administered, these medications act to inhibit the synthesis of folate, also known as folic acid or vitamin B9, which is necessary for the synthesis of DNA and RNA. As a result, they interfere with bacterial DNA and RNA synthesis, which ultimately kills the bacteria.
Copyright © 2023 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Cookies are used by this site.
USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.