Childhood and early-onset psychological disorders: Pathology review

Last updated: November 01, 2022

Childhood and early-onset psychological disorders: Pathology review

Pathology Review

Pathology Review

Seizures: Pathology review
Vasculitis: Pathology review
Tuberculosis: Pathology review
Headaches: Pathology review
Endocarditis: Pathology review
Hypothyroidism: Pathology review
Cardiomyopathies: Pathology review
Shock: Pathology review
Vertigo: Pathology review
Lymphomas: Pathology review
Dementia: Pathology review
Scleroderma: Pathology review
Pancreatitis: Pathology review
Appendicitis: Pathology review
Diverticular disease: Pathology review
Dyslipidemias: Pathology review
Hyperthyroidism: Pathology review
Hypopituitarism: Pathology review
Adrenal masses: Pathology review
Cervical cancer: Pathology review
Sjogren syndrome: Pathology review
Eating disorders: Pathology review
Microcytic anemia: Pathology review
Macrocytic anemia: Pathology review
Penile conditions: Pathology review
Nephrotic syndromes: Pathology review
Jaundice: Pathology review
Collagen disorders: Pathology review
Cirrhosis: Pathology review
Leukemias: Pathology review
Pneumonia: Pathology review
Nephritic syndromes: Pathology review
Gallbladder disorders: Pathology review
Neurocutaneous disorders: Pathology review
HIV and AIDS: Pathology review
Hypertension: Pathology review
Extrinsic hemolytic normocytic anemia: Pathology review
Heme synthesis disorders: Pathology review
Intrinsic hemolytic normocytic anemia: Pathology review
Non-hemolytic normocytic anemia: Pathology review
Coagulation disorders: Pathology review
Platelet disorders: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Thrombosis syndromes (hypercoagulability): Pathology review
Plasma cell disorders: Pathology review
Myeloproliferative disorders: Pathology review
Acyanotic congenital heart defects: Pathology review
Cyanotic congenital heart defects: Pathology review
Pericardial disease: Pathology review
Heart blocks: Pathology review
Ventricular arrhythmias: Pathology review
Supraventricular arrhythmias: Pathology review
Heart failure: Pathology review
Atherosclerosis and arteriosclerosis: Pathology review
Coronary artery disease: Pathology review
Cardiac and vascular tumors: Pathology review
Valvular heart disease: Pathology review
Aortic dissections and aneurysms: Pathology review
Peripheral artery disease: Pathology review
Deep vein thrombosis and pulmonary embolism: Pathology review
Cushing syndrome and Cushing disease: Pathology review
Diabetes mellitus: Pathology review
Neuroendocrine tumors of the gastrointestinal system: Pathology review
Multiple endocrine neoplasia: Pathology review
Parathyroid disorders and calcium imbalance: Pathology review
Diabetes insipidus and SIADH: Pathology review
Pituitary tumors: Pathology review
Thyroid nodules and thyroid cancer: Pathology review
Nasal, oral and pharyngeal diseases: Pathology review
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Malabsorption syndromes: Pathology review
Inflammatory bowel disease: Pathology review
Viral hepatitis: Pathology review
Colorectal polyps and cancer: Pathology review
Gastrointestinal bleeding: Pathology review
Blood transfusion reactions and transplant rejection: Pathology review
Bone disorders: Pathology review
Gout and pseudogout: Pathology review
Muscular dystrophies and mitochondrial myopathies: Pathology review
Myalgias and myositis: Pathology review
Rheumatoid arthritis and osteoarthritis: Pathology review
Seronegative and septic arthritis: Pathology review
Systemic lupus erythematosus (SLE): Pathology review
Bone tumors: Pathology review
Back pain: Pathology review
Cerebral vascular disease: Pathology review
Amnesia, dissociative disorders and delirium: Pathology review
Eye conditions: Inflammation, infections and trauma: Pathology review
Eye conditions: Refractive errors, lens disorders and glaucoma: Pathology review
Eye conditions: Retinal disorders: Pathology review
Spinal cord disorders: Pathology review
Central nervous system infections: Pathology review
Demyelinating disorders: Pathology review
Peroxisomal disorders: Pathology review
Movement disorders: Pathology review
Adult brain tumors: Pathology review
Neuromuscular junction disorders: Pathology review
Psychological sleep disorders: Pathology review
Traumatic brain injury: Pathology review
Congenital renal disorders: Pathology review
Urinary tract infections: Pathology review
Renal tubular acidosis: Pathology review
Renal tubular defects: Pathology review
Renal failure: Pathology review
Urinary incontinence: Pathology review
Acid-base disturbances: Pathology review
Electrolyte disturbances: Pathology review
Sexually transmitted infections: Vaginitis and cervicitis: Pathology review
Sexually transmitted infections: Warts and ulcers: Pathology review
Prostate disorders and cancer: Pathology review
Testicular tumors: Pathology review
Testicular and scrotal conditions: Pathology review
Cystic fibrosis: Pathology review
Pleural effusion, pneumothorax, hemothorax and atelectasis: Pathology review
Lung cancer and mesothelioma: Pathology review
Obstructive lung diseases: Pathology review
Restrictive lung diseases: Pathology review
Apnea, hypoventilation and pulmonary hypertension: Pathology review
Respiratory distress syndrome: Pathology review
Pigmentation skin disorders: Pathology review
Bacterial and viral skin infections: Pathology review
Papulosquamous and inflammatory skin disorders: Pathology review
Vesiculobullous and desquamating skin disorders: Pathology review
Viral exanthems of childhood: Pathology review
Acneiform skin disorders: Pathology review
Skin cancer: Pathology review
Medication overdoses and toxicities: Pathology review
Environmental and chemical toxicities: Pathology review
Miscellaneous genetic disorders: Pathology review
Renal and urinary tract masses: Pathology review
Anxiety disorders, phobias and stress-related disorders: Pathology Review
Developmental and learning disorders: Pathology review
Mood disorders: Pathology review
Psychiatric emergencies: Pathology review
Autosomal trisomies: Pathology review
Congenital neurological disorders: Pathology review
Adrenal insufficiency: Pathology review
Congenital gastrointestinal disorders: Pathology review
Lysosomal storage disorders: Pathology review
Glycogen storage disorders: Pathology review
Vaginal and vulvar disorders: Pathology review
Disorders of sex chromosomes: Pathology review
Schizophrenia spectrum disorders: Pathology review
Cytoskeleton and elastin disorders: Pathology review
Disorders of carbohydrate metabolism: Pathology review
Trauma- and stress-related disorders: Pathology review
Pediatric musculoskeletal disorders: Pathology review
Malingering, factitious disorders and somatoform disorders: Pathology review
Disorders of amino acid metabolism: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Disorders of fatty acid metabolism: Pathology review
Purine and pyrimidine synthesis and metabolism disorders: Pathology review
Fat-soluble vitamin deficiency and toxicity: Pathology review
Water-soluble vitamin deficiency and toxicity: B9, B12 and vitamin C: Pathology review
Water-soluble vitamin deficiency and toxicity: B1-B7: Pathology review
Zinc deficiency and protein-energy malnutrition: Pathology review
Pediatric brain tumors: Pathology review
Kidney stones: Pathology review
Esophageal disorders: Pathology review
Breast cancer: Pathology review
Amenorrhea: Pathology review
Drug misuse, intoxication and withdrawal: Hallucinogens: Pathology review
Drug misuse, intoxication and withdrawal: Stimulants: Pathology review
Drug misuse, intoxication and withdrawal: Alcohol: Pathology review
Drug misuse, intoxication and withdrawal: Other depressants: Pathology review
Personality disorders: Pathology review
Childhood and early-onset psychological disorders: Pathology review
Uterine disorders: Pathology review
Complications during pregnancy: Pathology review
Congenital TORCH infections: Pathology review
Ovarian cysts and tumors: Pathology review
Benign breast conditions: Pathology review
Disorders of sexual development and sex hormones: Pathology review

Transcript

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A 16 year old female, named Tayla, comes to the clinic because she’s been feeling urges to repeatedly blink her eyes, shake her head from side to side, or clear her throat. Tayla notes that she is able to suppress the urge for a while, but she eventually loses control of her actions. This all started a little over a year ago, and Tayla is under distress because her classmates often tease her about it. During the conversation, she suddenly utters an inappropriate curse word, and immediately goes on to say that she doesn’t know how that came out of her mouth. Physical examination reveals no neurological deficits and she shows normal cognitive skills for her age.

Okay, based on the initial presentation, Tayla seems to have some form of childhood or early-onset psychological disorder. These include several psychological conditions that typically have their onset during childhood, although some of these disorders may last into adulthood. As a consequence, these disorders can interfere with how the affected person functions independently in society, and impair everyday activities like working, studying, eating, and sleeping, as well as have an impact on their families.

For your exams, the most common childhood or early-onset psychological disorders are separation anxiety disorder, selective mutism, oppositional defiant disorder, conduct disorder, disruptive mood dysregulation disorder, tourette syndrome, and child abuse.

Let’s begin with separation anxiety disorder. That happens when separation from someone that the child is very attached to, like a parent, causes overwhelming or excessive fear and anxiety. In some cases, this can reach the point where it may lead to factitious physical complaints so that individuals can stay home and miss school. To be diagnosed as separation anxiety disorder, this needs to last for at least four weeks or more. Bear in mind, though, that this can be considered normal behavior until the age of 3 or 4.

Now, treatment includes cognitive behavioral therapy, or cbt for short, which is a type of talk therapy that primarily focuses on teaching the individual strategies to better cope with stress and social pressures, as well as identify the anxious patterns of thinking that might be influencing their disorder. Other approaches include play therapy, which uses play to help individuals deal with their anxiety, and family therapy, where parents and siblings can learn new ways to interact with the individual and help them when anxiety spikes.

Moving on to selective mutism, this is when individuals fail to speak at specific social situations, such as at school. The problem typically starts before the age of 5, and lasts for at least one month. Another high yield fact is that selective mutism is often accompanied by social anxiety disorder or social phobia, which is characterized by excessive anxiety caused by social or performance situations like meeting groups of new people, going on dates, and job interviews, where people feel like they are under scrutiny or being judged.

What’s important to remember here is that these individuals speak normally in other, presumably more comfortable situations, such as at home, and the failure to speak isn’t due to a lack of teaching or a communication disorder. Treatment of selective mutism typically comprises cognitive behavioral therapy, as well as play and family therapy. In some cases, medications might be recommended, especially selective serotonin reuptake inhibitors or ssris like fluoxetine, paroxetine, sertraline, citalopram, escitalopram.

Next is oppositional defiant disorder, or ODD for short. This is marked by angry or irritable mood, like temper loss; as well as argumentative or defiant behavior, which is when individuals frequently argue with authority figures; and vindictiveness or spitefulness, where individuals may feel resentful or believe that others are to blame for their own behaviors and may want to seek revenge. In order to be diagnosed with oppositional defiant disorder, these moods and behavioral patterns must be ongoing for at least 6 months. Treatment mainly involves cognitive behavioral therapy to change the child’s mood or feelings and improve their behavior.

Next is conduct disorder, where individuals recurrently violate other people’s basic rights, and may mistreat or show aggression to people or animals, steal from others, destroy property, or disregard moral values and norms of society. For your test, remember that to meet the diagnosis, individuals must be under 18 years of age. So if they are over the age of 18, it is diagnosed as antisocial personality disorder. And that’s a high yield fact! Treatment once again involves cognitive behavioral therapy.

Moving on to disruptive mood dysregulation disorder, which usually has its onset before the age of 10, and is characterized by recurrent explosive outbursts of intense anger and violence, sometimes causing injury to themselves or others. These outbursts occur in response to any real or perceived provocation, and are almost always out of proportion to the situation. For your exams, remember that these outbursts occur three or more times a week for at least one year. A unique characteristic of disruptive mood dysregulation disorder is that even in-between outbursts, these children are constantly irritable or angry. Treatment generally focused on changing their violent behaviors through cognitive behavioral therapy, while some individuals may also benefit from medications, such as stimulants or antipsychotics.

Next is tourette syndrome, a disorder characterized by tics, which are involuntary, brief, purposeless, and stereotypical movements or vocalizations that occur over and over, and aren’t side effects of some other disorder or substance abuse. For your exams, keep in mind that to diagnose tourette syndrome, three criteria must be met. First, the individual should present with at least two motor tics, such as twitching of the nose, jumping or head banging, as well as one vocal tic, which tend to manifest as grunting, barking, or throat clearing, but may also involve words, phrases, or sentences.

Some individuals may also present with specific vocal tics like echolalia, which is repeating the words or phrases of others, palilalia, which is repeating one’s own words, and a high yield one is coprolalia, which is verbally expressing inappropriate obscenities or curse words. And that’s actually the most widely known symptom of tourette syndrome, and certainly the one examiners love the most! The second criterium is that the onset of symptoms must be before 18 years of age. And third, the individual should have the symptoms for over a year.

Another high yield fact is that tourette syndrome is often associated with other psychiatric conditions, such as attention deficit hyperactivity disorder or adhd and autism spectrum disorder, as well as obsessive compulsive disorder or ocd, which is a specific type of anxiety disorder characterized by obsessions or recurrent and unwanted thoughts that usually lead to compulsions, which are actions performed to try and reduce the anxiety.

Treatment of tourette syndrome involves cognitive behavioral therapy to help individuals identify triggering events or feelings that precede tics to prevent them. In addition, individuals who don’t respond to cognitive behavioral therapy or present with distressing tics can be treated with medications, including alpha-2 receptor agonists like clonidine and guanfacine, typical antipsychotics like haloperidol, and atypical antipsychotics like risperidone or olanzapine.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "Diagnostic and Statistical Manual of Mental Disorders" A.P. Association and A.P.A.T.F.O.N.A. Statistics (1980)
  5. "Selective mutism: A review and integration of the last 15 years" Clinical Psychology Review (2009)
  6. "IN THIS ISSUE/ABSTRACT THINKING" Journal of the American Academy of Child & Adolescent Psychiatry (2010)
  7. "Tics and Tourette" Current Opinion in Pediatrics (2017)