Summary of Contracting the immune response and peripheral tolerance
Peripheral tolerance is immunological tolerance developed after autoreactive T and B cells mature and enter the periphery. These include the suppression of autoreactive cells by 'regulatory' T cells (Tregs) and the generation of hyporesponsiveness (anergy) in lymphocytes which encounter antigen in the absence of the co-stimulatory signals that accompany inflammation, or in the presence of co-inhibitory signals.
Flashcards on Contracting the immune response and peripheral tolerance
Contracting the immune response and peripheral tolerance
Decreased levels of lead to B-cell anergy, which means they won't mature into plasma cells.