Summary of MHC class I and MHC class II molecules
MHC class II
MHC (major histocompatibility complex) class II molecules are a family of molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells.
MHC class I
MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the body. Their function is to display fragments of non-self proteins from within the cell to cytotoxic T cells; this will trigger an immediate response from the immune system against the particular non-self antigen displayed with the help of MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation is often called the cytosolic or endogenous pathway.
Flashcards on MHC class I and MHC class II molecules
MHC class I and MHC class II molecules
is loaded onto MHC class II molecule following release of the invariant chain in an acidified endosome.