is most commonly gastric adenocarcinoma developing from the lining of the stomach. The most common cause is infection by the bacterium Helicobacter pylori
, which accounts for more than 60% of cases. Other causes include dietary nitrosamines (smoked foods), tobacco smoking
, achlorhydria, and chronic gastritis. This cancer often presents late, with weight loss, early satiety
, and in some cases acanthosis nigricans or Leser-Trélat sign.