Mumps virus

00:00 / 00:00


Mumps virus


0 / 8 complete

USMLE® Step 1 questions

0 / 1 complete

High Yield Notes

6 pages


Mumps virus

of complete


USMLE® Step 1 style questions USMLE

of complete

A 16-year-old boy is brought to the emergency department for evaluation of testicular pain and scrotal swelling. He had an episode of bilateral facial swelling along the jawline several days ago with associated fevers, headaches, and myalgias. The pain is worsened with movement. He has no dysuria. He is not sexually active. Records demonstrate his parents refused vaccinations throughout childhood. Temperature is 38.2°C (100.7°F), pulse is 98/min, and blood pressure is 122/84 mmHg. Physical examination reveals bilaterally enlarged and tender testicles. Stroking of the inner thigh bilaterally results in elevation of the testes. Which of the following is the most likely etiology of this patient’s clinical condition?  

Memory Anchors and Partner Content

External References

First Aid








Mumps p. 167

acute pancreatitis with p. 406

paramyxovirus p. 164, 166

Aseptic meningitis

mumps p. 167


mumps p. 167


mumps as cause p. 167

Pancreatitis p. 406

mumps p. 167

Paramyxoviruses p. 166

mumps p. 166


mumps p. 167


Content Reviewers

Mumps is a disease caused by the mumps virus, which is a member of the paramyxoviridae family.

This is actually a large family of viruses which includes measles virus and parainfluenza viruses, and all of these tend to affect children the most.

Mumps only affects humans and is spread by tiny respiratory droplets that are small enough to be carried short distances in the air, so mumps virus is extremely contagious and anyone near a person with mumps is at risk for getting the disease as well.

The mumps virus has a single strand of RNA and a viral polymerase enzyme surrounded by a phospholipid bilayer envelope studded with viral proteins hemagglutinin-neuraminidase, or HN protein, and fusion or F protein.

The HN protein allows the virus to stick to a potential host cell, and cut itself loose if necessary, and the F-protein which fuses the viral and cell membranes together allowing the mumps virus to enter the cell.

Once mumps enters a cell, the single stranded RNA, which is negative sense, gets transcribed by the viral polymerase enzyme, into a complementary positive sense strand of mRNA, which can then be translated by the host cell ribosomes into new copies of the envelope proteins and the viral polymerase, which get assembled into new viruses.

What also ends up happening with these, though, is that those HN and F-proteins on the cell surface now bind other cells, so they actually end up bind epithelial cells to one another, which forms a clump of connected cells called a multinucleated giant cell or a syncytium.

Mumps enters the body and first infects the epithelial cells of the nasopharynx, where it starts replicating and causing local damage to the tissue.

From there, it can cause viremia or virus in the blood, and reach various organs and tissues.

The mumps virus has tropism, or preference for, the parotid salivary glands, and the most classic finding in mumps is swelling of parotid salivary glands either on one side or on both sides, sometimes with an associated earache.


Mumps, also known as epidemic parotitis, is a viral disease caused by the mumps virus. Initial signs and symptoms often include fever, muscle pain, headache, and feeling tired. This is often followed by painful swelling of one or both parotid glands. Mumps can complicate into pancreatitis, meningitis, encephalitis, orchitis, and epididymitis.


Copyright © 2023 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.