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|HISTAMINE H2-RECEPTOR ANTAGONISTS|
|DRUG NAME||cimetidine (Tagamet HB), famotidine (Pepcid), nizatidine (Axid)|
|CLASS||Histamine H2 receptor antagonists|
|MECHANISM OF ACTION||Block H2 receptors in parietal cells of the stomach → decrease gastric acid secretion|
|ROUTE(S) OF ADMINISTRATION|
|CONTRAINDICATIONS AND CAUTIONS|
|NURSING CONSIDERATIONS||Assessment and monitoring: all Histamine H2 receptor antagonists|
Client education: all Histamine H2 receptor antagonists
Because of that, they can be used to treat peptic ulcers; gastroesophageal reflux disease, or GERD; and Zollinger-Ellison syndrome, which is a rare condition caused by gastrin-secreting tumors. In addition, histamine H2-receptor antagonists can be used to prevent stress-induced ulcers.
Now, gastric acid is secreted by the parietal cells, which have different membrane receptors that modulate their activity. One of them is the H2 histamine receptor.
Normally, the stomach is protected from the acidic environment by the mucus secreted by foveolar cells, and the esophagus is protected by the lower esophageal sphincter, which prevents gastric acid from coming back up.
Histamine H2-receptor antagonists block H2 receptors so histamine can’t bind them, which decreases gastric acid secretion, and in turn mitigates the harmful effects of gastric acid in these disorders.
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