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|PROTON PUMP INHIBITOR (PPIs)|
omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), esomeprazole (Nexium), dexlansoprazole (Dexilant)
|CLASS||Proton pump inhibitor (PPIs)|
|MECHANISM OF ACTION||Inhibit H+/K+-ATPase on parietal cells in the stomach → decrease gastric acid secretion|
|ROUTE(S) OF ADMINISTRATION|
|CONTRAINDICATIONS AND CAUTIONS|
|NURSING CONSIDERATIONS: PROTON PUMP INHIBITOR (PPIs)|
|ASSESSMENT AND MONITORING||All proton pump inhibitors|
|CLIENT EDUCATION||All proton pump inhibitors|
Proton pump inhibitors, or PPIs for short, are medications used to treat conditions like peptic ulcers, gastroesophageal reflux disorder or GERD, and Zollinger-Ellison syndrome, which is caused by a gastrin-secreting tumor that leads to excess gastric acid secretion which then results in peptic ulcers.
Now, proton pump inhibitors usually end in “-prazole”, and include medications that are administered orally, like omeprazole, lansoprazole, dexlansoprazole, rabeprazole; as well as medications available intravenously, like pantoprazole and esomeprazole.
Once administered, proton pump inhibitors act on the parietal cells in the stomach by binding to and inhibiting the H+/K+-ATPase or proton pumps.
These pumps are involved in the secretion of gastric acid by exchanging potassium ions from the lumen with hydronium from the cells. As a result, proton pump inhibitors ultimately decrease gastric acid secretion.
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