Antibiotics - Lincosamides: Nursing pharmacology

Lincosamides are a class of antibiotics used to treat severe infections caused by gram positive and anaerobic bacteria. The lincosamide family of antibiotics includes both clindamycin and lincomycin, however, lincomycin has been widely replaced by clindamycin in almost all of its uses.

Now, clindamycin is most often used to treat skin and soft tissue infections caused by staphylococci and streptococci. It can be active against community-acquired strains of methicillin resistant Staphylococcus aureus, or MRSA for short, an increasingly common cause of cutaneous infections. Additionally, clindamycin is indicated for the treatment of anaerobic infections caused by Bacteroides species and other anaerobes that often participate in mixed flora infections.

Consequently, it is often used in combination with cephalosporins or aminoglycosides to treat penetrating wounds of the abdomen and gut, infections originating in the female reproductive tract, and lung abscesses.

Finally, clindamycin may be used for the prophylaxis of endocarditis in clients with underlying valvular heart disease, as well as to treat Pneumocystis jirovecii pneumonia in clients with HIV infection.

For the treatment of systemic infections, clindamycin can be administered orally or by intravenous or intramuscular injection. Additionally, clindamycin can be used topically for the treatment of acne and rosacea, as well as intravaginally for the treatment of bacterial vaginosis.

All right now, once administered, clindamycin targets the 50S ribosomal subunit of the bacteria, thereby inhibiting protein synthesis and ultimately limiting the growth of bacteria. Although clindamycin has a primarily bacteriostatic effect, it can also act as a bactericidal antibiotic at higher concentrations.