Taste is believed to be one of the most pleasurable human special senses. The process involves a coordinated interaction between tastants in the environment and the microvilli of taste receptor cells in taste buds on the tongue. Circumvallate, fungiform, and foliate papillae are where the majority of taste buds are located within the oral cavity. After chemical tastants excite specific taste receptor epithelial cells, neurotransmitters are released to transduce the signal to afferent sensory nerves. Ultimately, the stimulus terminates in the insula, hypothalamus, and limbic system to determine and appreciate the gustatory sensation.
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