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Vestibulo-ocular reflex and nystagmus

Vestibulo-ocular reflex and nystagmus


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High Yield Notes
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Vestibulo-ocular reflex and nystagmus

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Content Reviewers:

Rishi Desai, MD, MPH

Vestibulo- refers to the vestibular apparatus which is in the inner ear, that helps maintain our balance, and ocular refers to the eyes.

So the vestibulo-ocular reflex is a reflex that starts in the vestibular apparatus, in response to head movement, and ends with movement of the eyes.

The inner ear, sometimes called the labyrinth, is a marvelous bit of engineering. On the outside, it has a tough bony shell - the bony labyrinth; and inside the bony labyrinth, there’s the membranous labyrinth.

The bony and membranous labyrinth help form all three parts of the inner ear.

The first is the vestibule, which is like a hallway that leads up to two other parts or rooms - the cochlea, towards the front of our head, that deals with hearing, and a second room towards the back of our head, that contains three semicircular canals - an anterior, a posterior and a lateral one - which play a role in balance.

Along with the semicircular canals, there are also two other balance-related structures in the vestibule - the utricle and the saccule.

Together, the semicircular canals, the utricle, and the saccule make up the vestibular apparatus, and each of these structures have special balance receptors called hair cells - which function like motion sensors, picking up different kinds of movement.

Hair cells in the semicircular canals detect changes in our dynamic equilibrium, like when we rotate our head, while those in the utricle and saccule detect changes in our head position in relation to horizontal or vertical acceleration - like when we feel pushed towards the back of the seat in a speeding car, or when we go up or down an elevator.

Now let’s switch gears and look at the eyes - pun intended! The eyes normally focus on an image that’s projected on the fovea - which is the central part of the retina. But, our head is almost always moving - from bopping ever so slightly when we walk, to turning when we want to take a sneak peek at a cute person walking by. So if our eyes weren’t moving along with our head, the image would bop up and down with every step we take.

On the outside of each eye, there are 6 extrinsic eye muscles - a superior and an inferior oblique muscle, a superior and an inferior rectus muscle, as well as a lateral and a medial rectus. These muscles contract or relax in order to adjust the direction of our gaze.

The vestibulo-ocular reflex has five components: a receptor that receives the stimulus, an afferent pathway, a central nervous system relay, an efferent pathway, and an effector that responds with a reaction.

So, let’s use an example - let’s say that you turn your head slightly to the right. This is our stimulus.

This stimulus is picked up by receptors - which are the hair cells in the left and right semicircular canals.

Now, each of the semicircular canals respond to different kinds of rotation, but in our example, simply rotating our head to the right engages the lateral semicircular canal in the left and right inner ear.

So, let’s look at just the right side. The right lateral semicircular canal ends with a dilated portion called the ampulla - which is lined by hair cells which are balance receptors.

These hair cells get their name because they have projections called cilia on top of them - kinda like a haircut.These projections are embedded in a gelatinous substance called the cupula.

When we turn our head to the right, this sets in motion a fluid called endolymph that can be found inside the membranous duct.

The endolymph moves in the opposite direction of movement - so to the left.

And the movement of the endolymph deflects the gel-like cupula as well as the cilia on the hair cells to the left. When the cilia bend in that way, it triggers the hair cells to generate an action potential.

This action potential travels through to nerve fibers that synapse with the hair cells.

These nerves converge to form the vestibular branch of the vestibulo-cochlear, or eighth cranial nerve.

This is our afferent pathway, that travels all the way to the part of the central nervous system called the brainstem - more specifically, to the right vestibular nuclei in the pons. This makes up the central nervous system relay.

Now, for the efferent pathway, things get interesting. From the right vestibular nucleus, nerve fibers cross over to the left abducens nucleus.

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  3. "Human Anatomy & Physiology" Pearson (2018)
  4. "Principles of Anatomy and Physiology" Wiley (2014)
  5. "Incidence and characteristics of voluntary nystagmus." Journal of Neurology, Neurosurgery & Psychiatry (1978)
  6. "Eyes on Target: What Neurons Must do for the Vestibuloocular Reflex During Linear Motion" Journal of Neurophysiology (2004)