Endometrial cancer is a cancer that arises from the endometrium. It is the most common gynecologic malignancy, and has a peak occurrence at 55-65 years of age. It presents with abnormal uterine bleeding in a postmenopausal woman and is typically preceded by endometrial hyperplasia. Risk factors include Lynch syndrome, diabetes
, obesity, prolonged use of estrogens
unopposed by progesterone
, nulliparity, and polycystic ovarian syndrome
. Treatment for all forms of endometrial cancer is total abdominal hysterectomy with bilateral salpingo-oophorectomy. All cancers stage II and onwards receive radiotherapy, with stage III and IV also receiving chemotherapy. The prognosis is better than that of ovarian cancer.