Category: Step 1

This USMLE Step 1 Question of the Day involves a 36-year-old patient for evaluation of treatment-resistant depression. None of their previous medications helped improved their symptoms. Based on the findings, identify the most likely diagnosis. A 36-year-old presents to their outpatient provider for evaluation of treatment-resistant depression. They have previously…

This USMLE Step 1 Question of the Day involves a 60-year-old woman with progressive cognitive decline, fluctuating mental clarity, mild tremors, slowed movements, and balance issues. She has also been seen conversing with her deceased partner. Based on these clinical features, identify the most likely diagnosis. A 60-year-old woman comes…

Prepare for USMLE Step 1 with this case! Learn about xeroderma pigmentosum, a rare genetic disorder causing extreme sensitivity to sunlight and increased risk of skin cancer due to defective DNA repair mechanisms. Understand its clinical manifestations, including pigmented skin changes, ocular damage, and neurological complications, for accurate diagnosis and…

Discover the case of a 42-year-old man with knee pain, red eyes, and foot lesions post-UTI treatment. Could it be reactive arthritis? A 42-year-old man comes to his primary care physician’s office for evaluation of right knee pain, red eyes, and lesions on soles of his feet. The patient states…

Learn about Tay-Sachs disease, an autosomal recessive neurodegenerative disorder characterized by regression of motor milestones, seizures, and a distinctive cherry-red macula. An 8-month-old girl is brought to the emergency department with a seizure-like episode. The parents state the patient started contracting her upper and lower extremities for 30 seconds. Her…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 56-year-old woman who reported a sensation of numbness on her mouth and intermittent twitching of her extremities. Physical examination demonstrates an intact incision over the anterior neck without…

The Rule of Nines is a method used in emergency departments to quickly estimate the extent of burns on a patient’s body. This USMLE® Step 1 Question of the Day will test your knowledge on this topic. A 25-year-old man is brought to the emergency department with severe burns on…

Learn about a USMLE® Step 1 question of the day related to systolic ejection murmur, specifically focusing on aortic stenosis. Discover the characteristics of this murmur and how to recognize it during auscultation. A 66-year-old man presents to a cardiologist for evaluation of a new heart murmur discovered at a…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 57-year-old man experiencing anxiety, hand tremor, and nausea post-total knee replacement, now in the emergency department. With a continuous morphine infusion and a history of advanced liver…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 25-year-old man who suffered head trauma in a bar altercation, resulting in loss of consciousness. Despite initial refusal for medical evaluation, he later exhibits alarming symptoms, including…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 6-year-old adopted boy diagnosed with autism spectrum disorder and Fragile X syndrome. Delve into the discussion with the physician, exploring the family pedigrees that unravel the genetic…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 6-month-old infant facing poor weight gain, weak cry, and muscle hypotonia. With genetic work-up pointing to a PDHA1 gene mutation and elevated serum lactate levels, can you…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 28-month-old with unusual clinical features. Can you identify the most likely cause behind the disseminated rash, hepatosplenomegaly, and distinctive facial and skeletal abnormalities?Test your diagnostic skills with…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 66-year-old man with altered mental status, headache, and more. Can you identify the fundoscopy finding that affects a diagnostic lumbar puncture? Test your diagnostic skills with this USMLE Step 1…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 23-year-old man who collapsed and started having tremors in the upper and lower extremities during a festival. Can you figure it out? A 23-year-old man is brought to the…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 35-year-old marathon runner with burning foot pain. Learn how to identify the underlying nerve compression causing his symptoms. Test your diagnostic skills with this USMLE Step 1 question. A 35-year-old…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 6-month-old boy which is brought to the clinic for a well-child visit. His mother expresses concern that  there is inward deviation of his left eye. The patient most likely…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a study delving into muscle anatomy through a human cadaveric model. Explore the intricate innervation of upper extremity, chest, and back muscles as a nerve root is stimulated, revealing specific…

Learn how a skilled pathologist meticulously analyzes cross-sectional slides of the spinal cord, uncovering the significance behind the asterisk-marked structure. Discover the intricate functions woven into this essential neural component. Eager to delve deeper? Find out more about the fascinating realm of neural anatomy, unraveling the complexities that define spinal…

Discover the case of a 57-year-old man with acute-onset right lower extremity pain in the emergency department. Explore the medical history and symptoms that led to a concerning diagnosis. Learn about the histological findings that indicate irreversible cellular injury in the affected extremity. Find out more here. A 57-year-old man presents…

Learn about the ventilation, perfusion, and V/Q ratio in a 47-year-old man who experienced shortness of breath after returning from Germany. Find out the implications of his medical history, symptoms, and diagnostic findings. A 47-year-old man presents to the emergency department for evaluation of shortness of breath. The symptoms developed…