Category: USMLE® Step 1

This USMLE Step 1 Question of the Day involves a 36-year-old patient for evaluation of treatment-resistant depression. None of their previous medications helped improved their symptoms. Based on the findings, identify the most likely diagnosis. A 36-year-old presents to their outpatient provider for evaluation of treatment-resistant depression. They have previously…

This USMLE Step 1 Question of the Day involves a 60-year-old woman with progressive cognitive decline, fluctuating mental clarity, mild tremors, slowed movements, and balance issues. She has also been seen conversing with her deceased partner. Based on these clinical features, identify the most likely diagnosis. A 60-year-old woman comes…

Prepare for USMLE Step 1 with this case! Learn about xeroderma pigmentosum, a rare genetic disorder causing extreme sensitivity to sunlight and increased risk of skin cancer due to defective DNA repair mechanisms. Understand its clinical manifestations, including pigmented skin changes, ocular damage, and neurological complications, for accurate diagnosis and…

Discover the case of a 42-year-old man with knee pain, red eyes, and foot lesions post-UTI treatment. Could it be reactive arthritis? A 42-year-old man comes to his primary care physician’s office for evaluation of right knee pain, red eyes, and lesions on soles of his feet. The patient states…

Learn about Tay-Sachs disease, an autosomal recessive neurodegenerative disorder characterized by regression of motor milestones, seizures, and a distinctive cherry-red macula. An 8-month-old girl is brought to the emergency department with a seizure-like episode. The parents state the patient started contracting her upper and lower extremities for 30 seconds. Her…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 56-year-old woman who reported a sensation of numbness on her mouth and intermittent twitching of her extremities. Physical examination demonstrates an intact incision over the anterior neck without…

The Rule of Nines is a method used in emergency departments to quickly estimate the extent of burns on a patient’s body. This USMLE® Step 1 Question of the Day will test your knowledge on this topic. A 25-year-old man is brought to the emergency department with severe burns on…

Learn about a USMLE® Step 1 question of the day related to systolic ejection murmur, specifically focusing on aortic stenosis. Discover the characteristics of this murmur and how to recognize it during auscultation. A 66-year-old man presents to a cardiologist for evaluation of a new heart murmur discovered at a…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 25-year-old man who suffered head trauma in a bar altercation, resulting in loss of consciousness. Despite initial refusal for medical evaluation, he later exhibits alarming symptoms, including…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 6-year-old adopted boy diagnosed with autism spectrum disorder and Fragile X syndrome. Delve into the discussion with the physician, exploring the family pedigrees that unravel the genetic…

This week, we are sharing another USMLE® Step 1-style practice question to test your knowledge of medical topics. Today’s case focuses on a 6-month-old infant facing poor weight gain, weak cry, and muscle hypotonia. With genetic work-up pointing to a PDHA1 gene mutation and elevated serum lactate levels, can you…