Childhood and early-onset psychological disorders: Pathology review

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Childhood and early-onset psychological disorders: Pathology review

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Anatomical terminology
Joints of the ankle and foot
Anatomy of the tibiofibular joints
DNA structure
DNA replication
Hair, skin and nails
Wound healing
Estrogens and antiestrogens
Skin cancer
Chronic granulomatous disease
Plasmodium species (Malaria)
VDJ rearrangement
Bile secretion and enterohepatic circulation
Normal heart sounds
Ascending and descending spinal tracts
Somatosensory pathways
Anatomy of the diencephalon
Independent assortment of genes and linkage
Anatomy of the cerebral cortex
Anatomy of the ventricular system
Basal ganglia: Direct and indirect pathway of movement
Anatomy of the basal ganglia
Anatomy of the descending spinal cord pathways
Anatomy of the ascending spinal cord pathways
Movement disorders: Pathology review
Eye conditions: Refractive errors, lens disorders and glaucoma: Pathology review
Anatomy of the eye
Anatomy of the oculomotor (CN III), trochlear (CN IV) and abducens (CN VI) nerves
Anatomy and physiology of the ear
Auditory transduction and pathways
Anatomy of the inner ear
Ischemic stroke
Stroke: Clinical
Anatomy of the brainstem
Anatomy of the limbic system
Pediatric ophthalmological conditions: Clinical
Anatomy of the nose and paranasal sinuses
Schizophrenia spectrum disorders: Clinical
Spinocerebellar ataxia (NORD)
Anatomy clinical correlates: Cerebellum and brainstem
Anatomy of the pharynx and esophagus
Somatic symptom disorders: Clinical
Malingering, factitious disorders and somatoform disorders: Pathology review
Factitious disorder
Major depressive disorder
Suicide
Major depressive disorder with seasonal pattern
Insomnia
Developmental and learning disorders: Pathology review
Childhood and early-onset psychological disorders: Pathology review
Disorders of consciousness: Clinical
Brain herniation
Epidural hematoma
Subdural hematoma
Subarachnoid hemorrhage
Hernias: Clinical
Hypothyroidism
ADHD: Information for patients and families (The Primary School)
Attention deficit hyperactivity disorder
Neurodevelopmental disorders: Clinical
Autism spectrum disorder
Bipolar and related disorders
Mood disorders: Clinical
Pediatric upper airway conditions: Clinical
Upper respiratory tract infection
Superficial structures of the neck: Anterior triangle
Superficial structures of the neck: Posterior triangle
Anxiety disorders: Clinical
Anxiety disorders, phobias and stress-related disorders: Pathology Review
Generalized anxiety disorder
Anatomy of the facial nerve (CN VII)
Bell palsy
Cranial nerves rap
Anatomy of the infratemporal fossa
Anatomy of the trigeminal nerve (CN V)
Temporomandibular joint dysfunction
Anatomy of the temporomandibular joint and muscles of mastication
Allergic rhinitis
Nasal polyps
Sinusitis
Rhinovirus
Nasal, oral and pharyngeal diseases: Pathology review
Pancoast tumor
Laryngitis
Laryngomalacia
Trauma- and stress-related disorders: Pathology review
Trauma- and stressor-related disorders: Clinical
Traumatic brain injury: Clinical
Dementia: Pathology review
Meningitis
Meningitis, encephalitis and brain abscesses: Clinical
Abscesses
Seizures: Pathology review
Seizures: Clinical
Febrile seizure
Sleep disorders: Clinical
Narcolepsy (NORD)
Sleep apnea
Syncope: Clinical
Anatomy clinical correlates: Oculomotor (CN III), trochlear (CN IV) and abducens (CN VI) nerves
Kidney histology
Hypertension
Movement of water between body compartments
Body fluid compartments
Glucocorticoids
Mineralocorticoids and mineralocorticoid antagonists
Adrenocorticotropic hormone
Regulation of renal blood flow
Hydration
Synthesis of adrenocortical hormones
Cortisol
Vitamin D
Renal system anatomy and physiology
Renal clearance
Complement system
Hyponatremia
Hyponatremia: Clinical
Hypernatremia
Hypernatremia: Clinical
Electrolyte disturbances: Pathology review
Hypokalemia
Hypokalemia: Clinical
Hyperkalemia
Hyperkalemia: Clinical
Action potentials in myocytes
Cardiac conduction system
Hyperparathyroidism
ECG cardiac infarction and ischemia
Myocardial infarction
Pericarditis and pericardial effusion
Pleural effusion
Long QT syndrome and Torsade de pointes
Cardiovascular: Pulse (for nursing assistant training)
Atherosclerosis and arteriosclerosis: Pathology review
Arterial disease
Aneurysms
Ischemia
Deep vein thrombosis
Familial hypercholesterolemia
Hypercholesterolemia: Clinical
Dyslipidemias: Pathology review
Kidney countercurrent multiplication
Insulins
Diabetes mellitus
Diabetes mellitus: Pathology review
Pulmonary embolism
Deep vein thrombosis and pulmonary embolism: Pathology review
Wolff-Parkinson-White syndrome
Thyroid and parathyroid gland histology
Thyroid hormones
Hypothyroidism: Pathology review
Hyperthyroidism: Pathology review
Hyperthyroidism: Clinical
Toxic multinodular goiter
Thyroid nodules and thyroid cancer: Clinical
Coagulation (secondary hemostasis)
Platelet plug formation (primary hemostasis)
Helping a patient with a rare disease
Diabetes mellitus: Clinical
Pancreas histology
Pancreatic secretion
Endocrine system anatomy and physiology
Miscellaneous hypoglycemics
Hypopituitarism
Hypopituitarism: Pathology review
Hypopituitarism: Clinical
Pituitary adenoma
Acromegaly
Gigantism
Diabetes insipidus and SIADH: Pathology review
Hypoglycemics: Insulin secretagogues
Liver histology
Liver anatomy and physiology
Cirrhosis
Cirrhosis: Pathology review
Cirrhosis: Clinical
Alcohol-associated liver disease
Primary biliary cholangitis
Parathyroid disorders and calcium imbalance: Pathology review
Phosphate, calcium and magnesium homeostasis
Parathyroid conditions and calcium imbalance: Clinical
Parathyroid hormone
Hypocalcemia
Hypercalcemia
Jaundice
Jaundice: Pathology review
Jaundice: Clinical
Hepatitis A and Hepatitis E virus
Hepatitis B and Hepatitis D virus
Hepatitis C virus
Adrenal gland histology
Primary adrenal insufficiency
Adrenal insufficiency: Pathology review
Adrenal insufficiency: Clinical
Cushing syndrome and Cushing disease: Pathology review
Cushing syndrome
Pheochromocytoma
Hyperaldosteronism
Gallstone ileus
Gallstones
Gallbladder disorders: Pathology review
Biliary colic
Ascending cholangitis
Gastrointestinal system anatomy and physiology
Clinical Skills: Abdominal Assessment
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Peptic ulcers and stomach cancer: Clinical
Gastric cancer
Gastrointestinal bleeding: Pathology review
Gastrointestinal bleeding: Clinical
Hashimoto thyroiditis
Chronic pancreatitis
Pancreatitis: Pathology review
Pancreatitis: Clinical
Acute pancreatitis
Pancreatic cancer
Malabsorption syndromes: Pathology review
Malabsorption: Clinical
Celiac disease
Short bowel syndrome (NORD)
Esophageal disorders: Clinical
Esophageal disorders: Pathology review
Gastroesophageal reflux disease (GERD)
Gastroesophageal reflux disease (GERD): Clinical
Eosinophilic esophagitis (NORD)
Diverticular disease: Pathology review
Anatomy of the gastrointestinal organs of the pelvis and perineum
Lesch-Nyhan syndrome
Sjogren syndrome
Non-steroidal anti-inflammatory drugs
Antihistamines for allergies
Eczematous rashes: Clinical
Atopic dermatitis
Urinary tract infections: Pathology review
Urinary tract infections: Clinical
Lower urinary tract infection
Papulosquamous and inflammatory skin disorders: Pathology review
Mechanisms of antibiotic resistance
Erythema multiforme
Congenital TORCH infections: Pathology review
Severe chronic neutropenia (NORD)
Lung cancer
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Clinical
Anaphylaxis
Epigenetics
Cell signaling pathways
Cell cycle
Necrosis and apoptosis
Human papillomavirus
Atrophy, aplasia, and hypoplasia
Estrogen and progesterone
Testosterone
Androgens and antiandrogens
Anatomy of the female urogenital triangle
Anatomy of the female reproductive organs of the pelvis
Anatomy and physiology of the female reproductive system
Cellulitis and erysipelas: Clinical sciences
Mesoderm
Development of the axial skeleton
Spinal cord disorders: Pathology review
Chest trauma: Clinical
Shock: Pathology review
Shock
Hypovolemic shock: Clinical sciences
Portal hypertension
Metabolic acidosis
Pulmonary embolism: Clinical sciences
Marfan syndrome
Anticoagulants: Heparin
Anticoagulants: Warfarin
Abdominal aortic aneurysm: Clinical sciences
Reading a chest X-ray
Chest X-ray interpretation: Clinical sciences
Approach to dyspnea: Clinical sciences
Bulimia nervosa
Anorexia nervosa
Lung volumes and capacities
Deep vein thrombosis: Clinical sciences
ECG basics
Multiple organ dysfunction syndrome (MODS): Clinical sciences
Sepsis: Clinical sciences
Stomach histology
Approach to non-healing wounds: Clinical sciences
Assessment of Thorax and Lungs
Bacterial and viral skin infections: Pathology review
Cellulitis
Necrotizing soft tissue infections: Clinical sciences
Necrotizing fasciitis
Clostridium perfringens
General anesthetics
Local anesthetics
Nitrogen and urea cycle
Surgical site infection: Clinical sciences
Disseminated intravascular coagulation
Congenital neurological disorders: Pathology review
Puberty and Tanner staging
Precocious puberty
Turner syndrome
Turner syndrome: Year of the Zebra
Disorders of sexual development and sex hormones: Pathology review
Congenital adrenal hyperplasia
5-alpha-reductase deficiency
Klinefelter syndrome
Disorders of sex chromosomes: Pathology review
Brachial plexus
Neonatal meningitis
Development of the fetal membranes
cGMP mediated smooth muscle vasodilators
Down syndrome (Trisomy 21)
Autosomal trisomies: Pathology review
Taking a good patient history
Chlamydia trachomatis infection: Clinical sciences
Sexually transmitted infections: Vaginitis and cervicitis: Pathology review
Neisseria gonorrhoeae infection: Clinical sciences
Testis, ductus deferens, and seminal vesicle histology
Anatomy and physiology of the male reproductive system
Hypoparathyroidism
Protein-calorie malnutrition: Clinical sciences
Zinc deficiency and protein-energy malnutrition: Pathology review
Water-soluble vitamin deficiency and toxicity: B1-B7: Pathology review
Water-soluble vitamin deficiency and toxicity: B9, B12 and vitamin C: Pathology review
Fat-soluble vitamin deficiency and toxicity: Pathology review
Disorders of carbohydrate metabolism: Pathology review
Galactosemia
Cholestatic liver disease
Infectious gastroenteritis: Clinical sciences
Cyclic vomiting syndrome (NORD)
Viral hepatitis
Hepatitis medications
Hepatitis C: Clinical sciences
Uremic encephalopathy: Clinical sciences
Alagille syndrome (NORD)
Alagille syndrome (NORD): Year of the Zebra
Adrenal insufficiency: Clinical sciences
Achondroplasia
Anatomy of the lymphatics of the neck
Anatomy of the inguinal region
Lymphatic system anatomy and physiology
Introduction to the lymphatic system
Kawasaki disease
Bordetella pertussis (Whooping cough)
Cystic fibrosis: Pathology review
Miscellaneous genetic disorders: Pathology review
Fragile X syndrome
Measles virus
Epstein-Barr virus (Infectious mononucleosis)
Disruptive, impulse control, and conduct disorders
Approach to syncope: Clinical sciences
Glycogen storage disease type I
Glycogen storage disease type II (NORD)
Disorders of fatty acid metabolism: Pathology review
Spinal muscular atrophy
Approach to urinary incontinence (GYN): Clinical sciences
Approach to hypothyroidism: Clinical sciences
Hypothyroidism medications
Approach to hyperthyroidism and thyrotoxicosis: Clinical sciences
Thyroid carcinoma: Clinical sciences
Anatomy clinical correlates: Anterior and posterior abdominal wall
Approach to abdominal wall and groin masses: Clinical sciences
Inguinal hernias: Clinical sciences
Approach to a postoperative fever: Clinical sciences
Chronic venous insufficiency
Venous insufficiency and ulcers: Clinical sciences

Transcript

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A 16 year old female, named Tayla, comes to the clinic because she’s been feeling urges to repeatedly blink her eyes, shake her head from side to side, or clear her throat. Tayla notes that she is able to suppress the urge for a while, but she eventually loses control of her actions. This all started a little over a year ago, and Tayla is under distress because her classmates often tease her about it. During the conversation, she suddenly utters an inappropriate curse word, and immediately goes on to say that she doesn’t know how that came out of her mouth. Physical examination reveals no neurological deficits and she shows normal cognitive skills for her age.

Okay, based on the initial presentation, Tayla seems to have some form of childhood or early-onset psychological disorder. These include several psychological conditions that typically have their onset during childhood, although some of these disorders may last into adulthood. As a consequence, these disorders can interfere with how the affected person functions independently in society, and impair everyday activities like working, studying, eating, and sleeping, as well as have an impact on their families.

For your exams, the most common childhood or early-onset psychological disorders are separation anxiety disorder, selective mutism, oppositional defiant disorder, conduct disorder, disruptive mood dysregulation disorder, tourette syndrome, and child abuse.

Let’s begin with separation anxiety disorder. That happens when separation from someone that the child is very attached to, like a parent, causes overwhelming or excessive fear and anxiety. In some cases, this can reach the point where it may lead to factitious physical complaints so that individuals can stay home and miss school. To be diagnosed as separation anxiety disorder, this needs to last for at least four weeks or more. Bear in mind, though, that this can be considered normal behavior until the age of 3 or 4.

Now, treatment includes cognitive behavioral therapy, or cbt for short, which is a type of talk therapy that primarily focuses on teaching the individual strategies to better cope with stress and social pressures, as well as identify the anxious patterns of thinking that might be influencing their disorder. Other approaches include play therapy, which uses play to help individuals deal with their anxiety, and family therapy, where parents and siblings can learn new ways to interact with the individual and help them when anxiety spikes.

Moving on to selective mutism, this is when individuals fail to speak at specific social situations, such as at school. The problem typically starts before the age of 5, and lasts for at least one month. Another high yield fact is that selective mutism is often accompanied by social anxiety disorder or social phobia, which is characterized by excessive anxiety caused by social or performance situations like meeting groups of new people, going on dates, and job interviews, where people feel like they are under scrutiny or being judged.

What’s important to remember here is that these individuals speak normally in other, presumably more comfortable situations, such as at home, and the failure to speak isn’t due to a lack of teaching or a communication disorder. Treatment of selective mutism typically comprises cognitive behavioral therapy, as well as play and family therapy. In some cases, medications might be recommended, especially selective serotonin reuptake inhibitors or ssris like fluoxetine, paroxetine, sertraline, citalopram, escitalopram.

Next is oppositional defiant disorder, or ODD for short. This is marked by angry or irritable mood, like temper loss; as well as argumentative or defiant behavior, which is when individuals frequently argue with authority figures; and vindictiveness or spitefulness, where individuals may feel resentful or believe that others are to blame for their own behaviors and may want to seek revenge. In order to be diagnosed with oppositional defiant disorder, these moods and behavioral patterns must be ongoing for at least 6 months. Treatment mainly involves cognitive behavioral therapy to change the child’s mood or feelings and improve their behavior.

Next is conduct disorder, where individuals recurrently violate other people’s basic rights, and may mistreat or show aggression to people or animals, steal from others, destroy property, or disregard moral values and norms of society. For your test, remember that to meet the diagnosis, individuals must be under 18 years of age. So if they are over the age of 18, it is diagnosed as antisocial personality disorder. And that’s a high yield fact! Treatment once again involves cognitive behavioral therapy.

Moving on to disruptive mood dysregulation disorder, which usually has its onset before the age of 10, and is characterized by recurrent explosive outbursts of intense anger and violence, sometimes causing injury to themselves or others. These outbursts occur in response to any real or perceived provocation, and are almost always out of proportion to the situation. For your exams, remember that these outbursts occur three or more times a week for at least one year. A unique characteristic of disruptive mood dysregulation disorder is that even in-between outbursts, these children are constantly irritable or angry. Treatment generally focused on changing their violent behaviors through cognitive behavioral therapy, while some individuals may also benefit from medications, such as stimulants or antipsychotics.

Next is tourette syndrome, a disorder characterized by tics, which are involuntary, brief, purposeless, and stereotypical movements or vocalizations that occur over and over, and aren’t side effects of some other disorder or substance abuse. For your exams, keep in mind that to diagnose tourette syndrome, three criteria must be met. First, the individual should present with at least two motor tics, such as twitching of the nose, jumping or head banging, as well as one vocal tic, which tend to manifest as grunting, barking, or throat clearing, but may also involve words, phrases, or sentences.

Some individuals may also present with specific vocal tics like echolalia, which is repeating the words or phrases of others, palilalia, which is repeating one’s own words, and a high yield one is coprolalia, which is verbally expressing inappropriate obscenities or curse words. And that’s actually the most widely known symptom of tourette syndrome, and certainly the one examiners love the most! The second criterium is that the onset of symptoms must be before 18 years of age. And third, the individual should have the symptoms for over a year.

Another high yield fact is that tourette syndrome is often associated with other psychiatric conditions, such as attention deficit hyperactivity disorder or adhd and autism spectrum disorder, as well as obsessive compulsive disorder or ocd, which is a specific type of anxiety disorder characterized by obsessions or recurrent and unwanted thoughts that usually lead to compulsions, which are actions performed to try and reduce the anxiety.

Treatment of tourette syndrome involves cognitive behavioral therapy to help individuals identify triggering events or feelings that precede tics to prevent them. In addition, individuals who don’t respond to cognitive behavioral therapy or present with distressing tics can be treated with medications, including alpha-2 receptor agonists like clonidine and guanfacine, typical antipsychotics like haloperidol, and atypical antipsychotics like risperidone or olanzapine.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "Diagnostic and Statistical Manual of Mental Disorders" A.P. Association and A.P.A.T.F.O.N.A. Statistics (1980)
  5. "Selective mutism: A review and integration of the last 15 years" Clinical Psychology Review (2009)
  6. "IN THIS ISSUE/ABSTRACT THINKING" Journal of the American Academy of Child & Adolescent Psychiatry (2010)
  7. "Tics and Tourette" Current Opinion in Pediatrics (2017)