Endometritis

Last updated: November 01, 2022

Endometritis

obs and gyn

obs and gyn

Anatomy of the pelvic girdle
Anatomy of the pelvic cavity
Anatomy of the breast
Arteries and veins of the pelvis
Nerves and lymphatics of the pelvis
Anatomy of the female urogenital triangle
Anatomy of the perineum
Anatomy of the female reproductive organs of the pelvis
Anatomy clinical correlates: Breast
Anatomy clinical correlates: Female pelvis and perineum
Development of the reproductive system
Mammary gland histology
Ovary histology
Fallopian tube and uterus histology
Cervix and vagina histology
Anatomy and physiology of the female reproductive system
Puberty and Tanner staging
Estrogen and progesterone
Menstrual cycle
Menopause
Pregnancy
Oxytocin and prolactin
Stages of labor
Breastfeeding
Precocious puberty
Delayed puberty
Klinefelter syndrome
Turner syndrome
Androgen insensitivity syndrome
5-alpha-reductase deficiency
Kallmann syndrome
Amenorrhea
Ovarian cyst
Premature ovarian failure
Polycystic ovary syndrome
Ovarian torsion
Krukenberg tumor
Ovarian sex-cord stromal tumors
Ovarian surface epithelial tumors
Ovarian germ cell tumors
Uterine fibroid
Endometriosis
Endometritis
Endometrial hyperplasia
Endometrial cancer
Choriocarcinoma
Cervical cancer
Pelvic inflammatory disease
Urethritis
Female sexual interest and arousal disorder
Orgasmic dysfunction
Genito-pelvic pain and penetration disorder
Mastitis
Fibrocystic breast changes
Intraductal papilloma
Phyllodes tumor
Paget disease of the breast
Breast cancer
Hyperemesis gravidarum
Gestational hypertension
Preeclampsia & eclampsia
Gestational diabetes
Cervical incompetence
Placenta previa
Placenta accreta
Placental abruption
Oligohydramnios
Polyhydramnios
Potter sequence
Intrauterine growth restriction
Preterm labor
Postpartum hemorrhage
Chorioamnionitis
Congenital toxoplasmosis
Congenital cytomegalovirus (NORD)
Congenital syphilis
Neonatal conjunctivitis
Neonatal herpes simplex
Congenital rubella syndrome
Neonatal sepsis
Neonatal meningitis
Miscarriage
Gestational trophoblastic disease
Ectopic pregnancy
Fetal hydantoin syndrome
Fetal alcohol syndrome
Disorders of sex chromosomes: Pathology review
Prostate disorders and cancer: Pathology review
Testicular tumors: Pathology review
Uterine disorders: Pathology review
Ovarian cysts and tumors: Pathology review
Cervical cancer: Pathology review
Vaginal and vulvar disorders: Pathology review
Benign breast conditions: Pathology review
Breast cancer: Pathology review
Complications during pregnancy: Pathology review
Congenital TORCH infections: Pathology review
Disorders of sexual development and sex hormones: Pathology review
Amenorrhea: Pathology review
Testicular and scrotal conditions: Pathology review
Sexually transmitted infections: Warts and ulcers: Pathology review
Sexually transmitted infections: Vaginitis and cervicitis: Pathology review
HIV and AIDS: Pathology review
Estrogens and antiestrogens
Progestins and antiprogestins
Androgens and antiandrogens
Aromatase inhibitors
Uterine stimulants and relaxants
Routine prenatal care: Clinical
Hypertensive disorders of pregnancy: Clinical
Antepartum hemorrhage: Clinical
Premature rupture of membranes: Clinical
Abnormal labor: Clinical
Vaginal versus cesarean delivery: Clinical
Postpartum hemorrhage: Clinical
Gestational trophoblastic disease: Clinical
Abdominal pain: Clinical
Amenorrhea: Clinical
Contraception: Clinical
Virilization: Clinical
Infertility: Clinical
Vulvovaginitis: Clinical
Sexually transmitted infections: Clinical
Abnormal uterine bleeding: Clinical
Ovarian cysts, cancer, and other adnexal masses: Clinical
Endometrial hyperplasia and cancer: Clinical
Cervical cancer: Clinical
Vaginal cancer: Clinical
Vulvar cancer: Clinical
Urinary incontinence: Pathology review
Preconception care: Clinical sciences
Antepartum care (first trimester): Clinical sciences
Antepartum care (second trimester): Clinical sciences
Antepartum care (third trimester): Clinical sciences
Fetal aneuploidy screening: Clinical sciences
Induction of labor: Clinical sciences
Pain management during labor: Clinical sciences
Approach to acute pelvic pain (GYN): Clinical sciences
Ectopic pregnancy: Clinical sciences
Early pregnancy loss: Clinical sciences
Anemia in pregnancy: Clinical sciences
Hemoglobinopathies in pregnancy: Clinical sciences
Approach to diabetes in pregnancy: Clinical sciences
Diabetes in pregnancy (GDM, T1DM, and T2DM): Clinical sciences
Group B streptococcus (GBS) colonization in pregnancy: Clinical sciences
Intraamniotic infection: Clinical sciences
Alcohol, tobacco, cannabinoid, and substance use in pregnancy: Clinical sciences
Asthma in pregnancy: Clinical sciences
Cholestasis of pregnancy: Clinical sciences
Nausea and vomiting of pregnancy: Clinical sciences
Approach to hypertensive disorders in pregnancy: Clinical sciences
Gestational hypertension, preeclampsia, eclampsia, and HELLP: Clinical sciences
Protraction and arrest disorders: Clinical sciences
Placenta previa and vasa previa: Clinical sciences
Placental abruption: Clinical sciences
Breast abscess: Clinical sciences
Mastitis: Clinical sciences
Approach to postpartum hemorrhage: Clinical sciences
Placenta accreta spectrum: Clinical sciences
Uterine atony: Clinical sciences
Late-term and postterm pregnancy: Clinical sciences
Well-patient care (GYN): Clinical sciences
Cervical cancer screening: Clinical sciences
Sexually transmitted infection screening (GYN): Clinical sciences
Emergency contraception: Clinical sciences
Permanent contraception (sterilization): Clinical sciences
Reversible contraception: Clinical sciences
Approach to vaginal discharge: Clinical sciences
Bacterial vaginosis: Clinical sciences
Chlamydia trachomatis infection: Clinical sciences
Neisseria gonorrhoeae infection: Clinical sciences
Pelvic inflammatory disease: Clinical sciences
Vaginal trichomoniasis: Clinical sciences
Vulvovaginal candidiasis: Clinical sciences
Approach to dysuria: Clinical sciences
Hepatitis B: Clinical sciences
Catheter-associated urinary tract infection: Clinical sciences
Lower urinary tract infection: Clinical sciences
Pyelonephritis: Clinical sciences
Approach to urinary incontinence (GYN): Clinical sciences
Adnexal torsion: Clinical sciences
Adenomyosis: Clinical sciences
Uterine leiomyoma: Clinical sciences
Approach to primary amenorrhea: Clinical sciences
Polycystic ovary syndrome (PCOS): Clinical sciences
Approach to postmenopausal bleeding: Clinical sciences
Primary dysmenorrhea: Clinical sciences
Approach to adnexal masses: Clinical sciences
Development of the fetal membranes
Development of the placenta
Development of the umbilical cord
Fetal circulation
Development of twins
Mood disorders: Pathology review
Urinary tract infections: Pathology review
Newborn management: Clinical
Mood disorders: Clinical
Perinatal infections: Clinical
Urinary tract infections: Clinical
Breast cancer: Clinical
Precocious and delayed puberty: Clinical
Congenital adrenal hyperplasia: Clinical

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Endometritis is an inflammation of the endometrium, which is the inner lining of the uterus.

It is usually caused by an infection of the endometrium from bacteria that normally live in the female lower genital tract, but it could also be caused by bacteria from outside the body.

The female reproductive system is divided into upper and lower genital tracts.

The upper genital tract consists of the uterus, ovaries, and fallopian tubes.

The lower genital tract in turn consists of the cervix, vagina and the external genitals, which includes the labia and the clitoris.

Now, The uterus consists of 3 layers, an outer thin layer called the perimetrium or the serosa, a middle smooth muscle layer called the myometrium, and the innermost layer, the endometrium.

The endometrium has two layers, an inner functional layer made up mainly of glands and supporting connective tissue, called stroma, and an outer thin basal layer which regenerates the overlying functional layer after each menstrual cycle.

Alright, normally, there are many species of bacteria living in the female’s lower genital tract, and this is called the normal flora.

These include Ureaplasma urealyticum, Peptostreptococcus and group B Streptococcus.

Under normal conditions, these bacteria live there happily without causing any harm, however, if they reach the upper genital tract, they can cause an infection like endometritis if they make it to the uterus.

Endometritis is a common problem during pregnancy because bacteria can easily reach the uterus during childbirth.

Okay, so normally the fetus is surrounded by membranes and amniotic fluid, and the uterus’s opening is sealed by a mucous plug.

This mucus plug has antimicrobial properties, preventing bacteria from reaching the uterus. Typically, during vaginal delivery, the mucus plug is shed, the cervix widens, and the membranes around the fetus rupture, so the baby can be delivered.

However, bacteria in the lower genital tract can take advantage of this, and sneak through the opening up to the uterus, causing endometritis.

To make matters worse, under certain conditions, bacteria can have even more time to reach the endometrium.

This can occur when there’s prolonged labor, and premature rupture of membranes, where the membranes around the fetus have ruptured before the onset of labor.

In addition, if the amniotic fluid or the membranes around the fetus become infected, a condition known as chorioamnionitis, the infection can spread to the nearby endometrium causing it to be infected as well.

In addition, people who give birth by cesarean section are even more likely to have endometritis after childbirth.

This is because cesarean section makes it easier for the bacteria in the lower genital tract to reach the endometrium, and even bacteria from outside the body can make their way in.

Endometritis can also occur when placental or fetal tissues are not completely removed from the uterus after delivery or abortion.

These tissues provide a good environment for bacteria to grow and cause an infection in the uterus.

Now, apart from childbirth, there are other factors that makes it easier for bacteria from the lower genital tract to reach the endometrium, even in non-pregnant females.

This can occur during hysteroscopy, where the inside of the uterus is viewed using a camera inserted through the vagina, and when there’s an intrauterine contraceptive device, which has a thread that reaches down to the cervix or the vagina.

When these devices are inserted into the uterus, they might introduce forign bacteria accidentally.

Finally, endometritis can be caused by outside bacteria such as Chlamydia trachomatis or Neisseria gonorrhoeae, which are sexually transmitted infections.

Also, some cases of endometritis can occur in a female with tuberculosis, in which Mycobacterium tuberculosis spreads from the lungs into the blood and travels to other organs such as the uterus.

Alright, endometritis can be acute or chronic. People with acute endometritis, can present with fever, abnormal uterine bleeding, lower abdominal pain, dysuria, which is painful urination, or dyspareunia, which means pain during sexual intercourse.

When endometritis occurs after childbirth, the lochia, which is the normal vaginal discharge after giving birth, can become purulent, meaning yellowish, and foul smelling.

Key Takeaways

Endometritis refers to inflammation of the endometrium, the inner lining of the uterus. It is usually caused by normal flora of the genital tract if the endometrium is breached, but can also be caused by sexually transmitted infections, such as Chlamydia trachomatis and Neisseria gonorrhoeae infections.

Common symptoms are fever, pain in the pelvis or lower abdomen, abnormal vaginal discharge, and painful sexual intercourse. Procedures which can lacerate the endometrium such as childbirth, abortion, surgery on the uterus or other pelvic organs, and insertion of an intrauterine contraceptive device (IUD), all increase a chance of having endometritis.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
  5. "An in vitro study of antibacterial properties of the cervical mucus plug in pregnancy" American Journal of Obstetrics and Gynecology (2001)
  6. "The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology" American Journal of Obstetrics and Gynecology (2018)