Laryngomalacia

Laryngomalacia

Record

Record

Familial hypercholesterolemia
Hypertriglyceridemia
Atrioventricular nodal reentrant tachycardia (AVNRT)
Primary adrenal insufficiency
Thyroid eye disease (NORD)
Autoimmune polyglandular syndrome type 1 (NORD)
Opsoclonus myoclonus syndrome (NORD)
Acoustic neuroma (schwannoma)
Nasal polyps
Sleep apnea
Retropharyngeal and peritonsillar abscesses
Esophageal cancer
Gastroesophageal reflux disease (GERD)
Laryngomalacia
Laryngitis
Bacterial epiglottitis
Short bowel syndrome (NORD)
Abdominal hernias
Portal hypertension
Alpha 1-antitrypsin deficiency
Alpha-thalassemia
Beta-thalassemia
Iron deficiency anemia
Sideroblastic anemia
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Autoimmune hemolytic anemia
Sickle cell disease (NORD)
Anemia of chronic disease
Folate (Vitamin B9) deficiency
Vitamin B12 deficiency
Acute intermittent porphyria
Thrombotic thrombocytopenic purpura
Von Willebrand disease
Heparin-induced thrombocytopenia
Antithrombin III deficiency
Factor V Leiden
Protein C deficiency
Protein S deficiency
Myelodysplastic syndromes
Polycythemia vera (NORD)
Myelofibrosis (NORD)
Essential thrombocythemia (NORD)
Langerhans cell histiocytosis
Waldenstrom macroglobulinemia
Abscesses
Cytomegalovirus infection after transplant (NORD)
Vitiligo
Coxsackievirus
Human herpesvirus 6 (Roseola)
Parvovirus B19
Human herpesvirus 8 (Kaposi sarcoma)
Developmental dysplasia of the hip
Klumpke paralysis
Meniscus tear
Compartment syndrome
Osteoporosis
Osteomalacia and rickets
Lordosis, kyphosis, and scoliosis
Scleroderma
Spinocerebellar ataxia (NORD)
Early infantile epileptic encephalopathy (NORD)
von Hippel-Lindau disease
Focal segmental glomerulosclerosis (NORD)
Endometritis
Pelvic inflammatory disease
Congenital cytomegalovirus (NORD)
Sinusitis
Congenital pulmonary airway malformation
Chronic bronchitis
Idiopathic pulmonary fibrosis
Pancoast tumor
Mesothelioma

Flashcards

Laryngomalacia

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“Laryngo” refers to the larynx and “malacia” refers to a body tissue that is soft, so laryngomalacia is a developmental condition where the larynx doesn’t form correctly and ends up being soft and floppy.

Normally, the epiglottis, a flap of cartilage located just above the vocal cords, makes a firm arc over the airway.

It’s connected to the larynx by cartilaginous structures called aryepiglottic folds.

In children born with laryngomalacia, the aryepiglottic folds are shorter than normal, so they pull the normally arc-shaped epiglottis down into a distinctive omega shape.

Weak laryngeal muscle tone is thought to cause the condition, but the exact mechanism isn’t well understood.

The cartilaginous tissues are also softer than normal, so they flop into the airway.

That means that when the child breathes, that floppy structure gets sucked into the airway, causing stridor which is a high-pitched, whistling sound during breathing.

In some cases the obstruction of the airway can be so bad that it can make breathing difficult.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
  5. "Familial laryngomalacia: A case report" The Laryngoscope (1976)
  6. "Autosomal dominant congenital laryngomalacia" American Journal of Medical Genetics (1992)