Syphilis is a sexually-transmitted disease caused by the bacterium Treponema pallidum.
There are 3 stages. Primary Syphilis is characterized by localized disease with a painless chancre in the genital region. Secondary Syphilis is characterized by disseminated disease, constitutional symptoms, rash on hands and soles, condyloma lata, lymphadenopathy, and patchy hair loss. Tertiary Syphilis consists of gummas, neurosyphilis with tabes dorsalis and Argyll-Robertson pupils. Congenital syphilis is a subtype in neonates acquired from the mother in the second and third trimesters of pregnancy, that presents with facial anomalies like snuffles, a saddle nose, Hutchinson teeth, mulberry molars, short maxillae, saber shins, and deafness due to a cranial nerve VIII palsy. Diagnosis is with VDRL or RPR, and is confirmed with FTA-ABS. Treatment is with penicillin G