Gilbert's syndrome
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Gilbert's syndrome
GI Phase 2
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Flashcards
Gilbert's syndrome
0 of 7 complete
Questions
USMLE® Step 1 style questions USMLE
0 of 3 complete
A 25-year-old man comes to his family medicine PA seeking evaluation of jaundice. Two days ago, the patient participated in a marathon race. He had a similar episode in college after an episode of binge drinking. Past medical history is notable for seasonal allergies and hepatitis A infection, which he acquired one-year ago while travelling overseas. In the office, his temperature is 37.5°C (99.5°F), blood pressure is 118/65 mmHg, and pulse is 67/min. Physical examination shows scleral icterus and diffuse jaundice. Cardiac, pulmonary, and abdominal exams are noncontributory. Urinalysis reveals no significant findings. The patient’s blood work reveals the following findings:
Which of the following best explains the underlying cause of this patient’s condition?
| Laboratory value | Result |
| Hemoglobin | 14.2 mg/dL (reference range: 13.5-17.5 mg/dL) |
| Leukocyte count | 6,800/mm3 (reference range: 4,500-11,000/mm3) |
| Total bilirubin | 4.1 mg/dL (reference range: 0.1-1 mg/dL) |
| Conjugated bilirubin | 0.2 mg/dL (reference range: 0.0-0.3 mg/dL) |
| Alanine aminotransferase | 14 U/L (reference range: 8-40 U/L) |
| Aspartate aminotransferase | 17 U/L (reference range: 8-40 U/L) |
Which of the following best explains the underlying cause of this patient’s condition?
Key Takeaways
Gilbert's syndrome is a genetic disorder that affects how the liver conjugates bilirubin. People with Gilbert's syndrome have mild jaundice, which unusually appears under stressful conditions. The disorder is typically passed down through families in an autosomal recessive pattern, meaning both parents will pass on the gene for a child to be affected.