Biliary atresia
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Last updated
07-28-2019
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Osmosis: Biliary atresia. (2019, August 23). Retrieved from (https://www.osmosis.org/learn/Biliary_atresia).
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Summary of Biliary atresia
Biliary atresia
Biliary atresia, also known as extrahepatic ductopenia and progressive obliterative cholangiopathy, is a childhood disease of the liver in which one or more bile ducts are abnormally narrow, blocked, or absent. It can be congenital or acquired.
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Transcript for Biliary atresia
Content Reviewers:
Rishi Desai, MD, MPHBiliary atresia
Atresia refers to the obstruction or absence of a lumen or passageway, biliary has to do with the bile, bile ducts, or gallbladder, so biliary atresia is when there’s some sort of blockage, deformity, or even total absence of a bile duct.
Biliary atresia specifically refers to newborns or young infants, and it can be a congenital defect, meaning something that happens during fetal development, but more commonly it’s some sort of inflammation that happens soon after birth that leads to destruction of the bile ducts.
There isn’t a definitive cause of biliary atresia; but it’s generally thought that some viral or toxic substance might induce the inflammation.
Some genetic mutations have also been suggested—like a mutation in the CFC1 gene which is involved in development of the left-right embryonic axis. Mutations with this gene have been linked to other congenital defects as well.
At any rate, the mechanisms and pathogenesis are still pretty foggy, and it likely depends on a combinations of genetic and environmental factors.
Newborns with biliary atresia usually develop jaundice.
Since there’s some destruction or deformity of the bile ducts, eventually there’s an obstruction to bile flow right?