Whipple's disease

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Whipple's disease

GI

GI

Anatomy of the pharynx and esophagus

Anatomy of the oral cavity

Anatomy of the salivary glands

Anatomy of the tongue

Anatomy of the anterolateral abdominal wall

Anatomy of the abdominal viscera: Blood supply of the foregut, midgut and hindgut

Anatomy of the abdominal viscera: Esophagus and stomach

Anatomy of the abdominal viscera: Small intestine

Anatomy of the abdominal viscera: Large intestine

Anatomy of the abdominal viscera: Pancreas and spleen

Anatomy of the gastrointestinal organs of the pelvis and perineum

Anatomy of the abdominal viscera: Innervation of the abdominal viscera

Anatomy of the abdominal viscera: Liver, biliary ducts and gallbladder

Anatomy of the diaphragm

Anatomy of the inguinal region

Anatomy of the muscles and nerves of the posterior abdominal wall

Anatomy of the peritoneum and peritoneal cavity

Anatomy clinical correlates: Anterior and posterior abdominal wall

Anatomy clinical correlates: Viscera of the gastrointestinal tract

Anatomy clinical correlates: Peritoneum and diaphragm

Anatomy clinical correlates: Other abdominal organs

Development of the digestive system and body cavities

Development of the gastrointestinal system

Development of the teeth

Development of the tongue

Gallbladder histology

Esophagus histology

Stomach histology

Small intestine histology

Colon histology

Liver histology

Pancreas histology

Gastrointestinal system anatomy and physiology

Anatomy and physiology of the teeth

Liver anatomy and physiology

Enteric nervous system

Esophageal motility

Gastric motility

Gastrointestinal hormones

Chewing and swallowing

Carbohydrates and sugars

Fats and lipids

Vitamins and minerals

Intestinal fluid balance

Pancreatic secretion

Bile secretion and enterohepatic circulation

Prebiotics and probiotics

Cleft lip and palate

Congenital diaphragmatic hernia

Tracheoesophageal fistula

Pyloric stenosis

Oral candidiasis

Aphthous ulcers

Temporomandibular joint dysfunction

Gingivitis and periodontitis

Dental caries disease

Barrett esophagus

Plummer-Vinson syndrome

Mallory-Weiss syndrome

Boerhaave syndrome

Gastroesophageal reflux disease (GERD)

Zenker diverticulum

Diffuse esophageal spasm

Esophageal cancer

Eosinophilic esophagitis (NORD)

Gastric dumping syndrome

Cyclic vomiting syndrome

Gastroenteritis

Meckel diverticulum

Imperforate anus

Hirschsprung disease

Intestinal atresia

Intestinal malrotation

Necrotizing enterocolitis

Intussusception

Small bowel bacterial overgrowth syndrome

Short bowel syndrome (NORD)

Lactose intolerance

Whipple's disease

Protein losing enteropathy

Microscopic colitis

Ulcerative colitis

Bowel obstruction

Intestinal adhesions

Gallstone ileus

Abdominal hernias

Inguinal hernia

Small bowel ischemia and infarction

Ischemic colitis

Familial adenomatous polyposis

Peutz-Jeghers syndrome

Gardner syndrome

Juvenile polyposis syndrome

Colorectal polyps

Colorectal cancer

Carcinoid syndrome

Irritable bowel syndrome

Diverticulosis and diverticulitis

Rectal prolapse

Inflammatory bowel disease: Pathology review

Salmonella (non-typhoidal)

Clostridium perfringens

Bacillus cereus (Food poisoning)

Listeria monocytogenes

Hepatitis A and Hepatitis E virus

Clostridium botulinum (Botulism)

Pancreatitis: Pathology review

Gallbladder disorders: Pathology review

Pancreatic cancer

Colorectal polyps and cancer: Pathology review

Key Takeaways

Whipple's disease is a rare, systemic and chronic infectious disease caused by the bacterium Tropheryma whipplei. The disease primarily causes malabsorption, but can also affect multiple systems in the body including the gastrointestinal tract, joints, and central nervous system. Weight loss, diarrhea, joint pain, arthritis, fever, fatigue, and muscle weakness are common symptoms. The disease is significantly more common in men. Whipple's disease can usually be cured with long-term antibiotic therapy such as ceftriaxone and Trimethoprim-Sulfamethoxazole; untreated, the disease is ultimately fatal.